| Identification | Back Directory | [Name]
Dihydrochloride monohydrate | [CAS]
60789-62-0 | [Synonyms]
Clocapramine hydrochloride hydrate
Clocapramine dihydrochloride hydrate
3-Chlorocarpipramine hydrochloride hydrate
Clocapramine hydrochloride hydrate (3-Chlorocarpipramine hydrochloride hydrate)
Clocapramine hydrochloride hydrate (Synonyms: 3-Chlorocarpipramine hydrochloride hydrate) | [Molecular Formula]
C28H40Cl2N4O2 | [MDL Number]
MFCD31729545 | [MOL File]
60789-62-0.mol | [Molecular Weight]
535.55 |
| Hazard Information | Back Directory | [Uses]
Clocapramine hydrochloride hydrate is an antagonist of the D2 and 5-HT2A receptors. | [in vivo]
Clocapramine shows the lowest potency for D2-occupancy in vivo[1]. An in vivo receptor binding technique is used to evaluate the binding profiles of typical and atypical antipsychotic drugs to striatal dopamine-D2 and frontal serotonin-5-HT2 receptors in a rat brain using more specific ligands. Clocapramine produces ratios of potency in occupying 5-HT2 versus D2 receptors that fall between these two groups (ED50 of 14.5 mg/kg for D2, 4.9 mg/kg for 5-HT2)[2]. | [IC 50]
D2 Receptor; 5-HT2A Receptor | [References]
[1] Schotte A, et al. In vitro receptor binding and in vivo receptor occupancy in rat and guinea pig brain: risperidone compared with antipsychotics hitherto used. Jpn J Pharmacol. 1995 Dec;69(4):399-412. DOI:10.1254/jjp.69.399
[2] Sumiyoshi T, et al. Atypicality of several antipsychotics on the basis of in vivo dopamine-D2 and serotonin-5HT2 receptor occupancy. Neuropsychopharmacology. 1995 Feb;12(1):57-64. DOI:10.1038/sj.npp.1380239 |
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