ChemicalBook--->CAS DataBase List--->61276-17-3

61276-17-3

61276-17-3 Structure

61276-17-3 Structure
IdentificationMore
[Name]

Verbascoside
[CAS]

61276-17-3
[Synonyms]

JC 160
KUSAGININ
ACTEOSIDE
Acetoside
NSC 603831
Russetinol
Verbacoside
VERBASCOSIDE
StereosperMin
ISOVERBASCOSIDE
Verbascoside ,98%
VERBASCOSIDE WITH HPLC
Acteoside(Verbascoside)
Verbascoside(Acteoside)
Distinctive PhytosteM Lilac
3,4-Dihydroxyphenethyl alcohol acteoside
Extract from Verbena minutiflora (B864379)
Verbascoside, froM Cistanche deserticola Y.C.Ma
4-(3-(3,4-dihydroxyphenyl)-2-propenoate),(e)-beta-d-yl)
glucopyranoside,2-(3,4-dihydroxyphenyl)ethyl3-o-(6-deoxy-alpha-l-mannopyranos
2-(3,4-Dihydroxyphenyl)ethyl 3-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranoside 4-[(E)-3-(3,4-dihydroxyphenyl)propenoate]
B-D-GLUCOPYRANOSIDE, 2-(3,4-DIHYDROXYPHENYL)ETHYL 3-O-(6-DEOXY-ALPHA-L-MANNOPYRANOSYL)-,4-[3-(3,4-DIHYDROXYPHENYL)-2-PROPENOATE],(E)-
ACTEOSIDE :B-D-GLUCOPYRANOSIDE, 2-(3,4-DIHYDROXYPHENYL)ETHYL 3-O-(6-DEOXY-A-L-MANNOPYRANOSYL)-,4-[3-(3,4-DIHYDROXYPHENYL)-2-PROPENOATE],(E)-,
[(2R,3R,4R,5R,6R)-6-[2-(3,4-Dihydroxyphenyl)ethoxy]-5-hydroxy-2-(hydroxymethyl)-4-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-3-yl] (E)-3-(3,4-dihydroxyphenyl)prop-2-enoate
Verbascoside [(2R,3R,4R,5R,6R)-6-[2-(3,4-Dihydroxyphenyl)ethoxy]-5-hydroxy-2-(hydroxymethyl)-4-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-3-yl] (E)-3-(3,4-dihydroxyphenyl)prop-2-enoate
[Molecular Formula]

C29H36O15
[MDL Number]

MFCD06798947
[Molecular Weight]

624.59
[MOL File]

61276-17-3.mol
Questions And AnswerBack Directory
[Description]

Verbascoside is isolated from Lantana camara, acts as an ATP-competitive inhibitor of PKC, with an IC50 of 25 µM, and has antitumor, anti-inflammatory and antineuropathic pain activity.

[Natural occurrences]

Verbascoside can be found in species in all the families of the order Lamiales (syn. Scrophulariales). Only two examples are known from outside the order,in the clade Asterids.

[Mechanism of action]

It is known, that amyloid fibrils accumulation in cerebral can easily lead to neurodegenerative disorders. Acteoside has been reported to inhibit Aβ42 aggregation by activating nuclear translocation of the transcription factor NF-E2-related factor 2 (Nrf2), increasing heme oxygenase-1 (HO-1) expression. It has also been shown that acteoside could decrease nitric oxide synthase (NOS) activity and caspase-3 expression.

Chemical PropertiesBack Directory
[Melting point ]

232℃
[Boiling point ]

908.8±65.0 °C(Predicted)
[density ]

1.60±0.1 g/cm3(Predicted)
[storage temp. ]

Sealed in dry,Room Temperature
[pka]

9.31±0.10(Predicted)
[Detection Methods]

NMR,HPLC
[InChIKey]

FBSKJMQYURKNSU-ZLSOWSIRSA-N
[CAS DataBase Reference]

61276-17-3(CAS DataBase Reference)
Safety DataBack Directory
[Safety Statements ]

24/25
[WGK Germany ]

2
[RTECS ]

LZ5786000
[HS Code ]

29389090
[Toxicity]

LD50 oral in rat: > 5gm/kg
Hazard InformationBack Directory
[Chemical Properties]

White solid
[Uses]

Verbascoside is an agent producing effects on anti-GBM nephritis in rats. Effective agent against glomerulonephritis. Phenolic anti-oxidant agent.
[Enzyme inhibitor]

This plant glycoside and antioxidant (FW = 624.60 g/mol; CAS 61276-173), also known as verbascoside, inhibits TNFa-mediated apoptosis in LPSstimulated macrophages as well as 1-methyl-4-phenylpyridiniuminduced apoptosis in cerebellar granule neurons. It also inhibits proliferation of human promyelocytic HL-60 leukemia cells by inducing cell cycle arrest at the G0/G1 phase, followed by differentiation into monocytes. Acteoside inhibits PMA-induced invasion and migration of human fibrosarcoma cells by Ca2+-dependent CaMK/ERK and JNK/NFκB-signaling pathways. Acteoside thus shows the potential as antimetastatic agent. Another intriguing finding is that acteoside inhibits amyloid-β aggregation. Target(s): aldose reductase; protein kinase C; integrase, HIV-1; peptidyl-dipeptidase A, or angiotensin-converting enzyme; tyrosinase, or monophenol monooxygenase; 5-lipoxygenase, or arachidonate 5-lipoxygenase.
61276-17-3 suppliers list
Company Name: Shanghai Standard Technology Co., Ltd.
Tel: 18502101150
Website: www.nature-standard.com
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: +86-0371-55170693 +86-19937530512 , +86-19937530512
Website: http://www.tianfuchem.net/
Company Name: Hangzhou FandaChem Co.,Ltd.
Tel: +8615858145714 , +8615858145714
Website: http://www.fandachem.com
Company Name: Shanghai Zheyan Biotech Co., Ltd.
Tel: 18017610038
Website: www.chemicalbook.com/ShowSupplierProductsList30845/0.htm
Company Name: Chengdu GLP biotechnology Co Ltd
Tel: 028-87075086 13350802083 , 13350802083
Website: www. GLP-China.com
Company Name: Chengdu Biopurify Phytochemicals Ltd.
Tel: +8618482058008 , +8618482058008
Website: https://www.chemicalbook.com/ShowSupplierProductsList31191/0.htm
Company Name: Nanjing Dolon Biotechnology Co.,Ltd.
Tel: 18905173768
Website: www.chemicalbook.com/ShowSupplierProductsList31215/0.htm
Company Name: Hubei Jusheng Technology Co.,Ltd.
Tel: 86-18871470254
Website: www.hubeijusheng.com
Company Name: Xi'an Kono chem co., Ltd.,
Tel: 029-86107037 13289246953 , 13289246953
Website: www.konochem.com
Company Name: NanJing Spring & Autumn Biological Engineering CO., LTD.
Tel: +8613815430202 , +8613815430202
Website: https://www.chemistrynatural.com/
Company Name: BOC Sciences
Tel: 631-4854226
Website: https://www.chemicalbook.com/ShowSupplierProductsList518419/0.htm
Company Name: career henan chemical co
Tel: +86-0371-86658258
Website: www.coreychem.com
Company Name: Antai Fine Chemical Technology Co.,Limited
Tel: 18503026267 , 18503026267
Website:
Company Name: SHANGHAI T&W PHARMACEUTICAL CO., LTD.
Tel: 021-61999440
Website: www.trustwe.com
Company Name: Neostar United (Changzhou) Industrial Co., Ltd.
Tel: +86-519-519-85557386
Website: http://www.neostarunited.com
Company Name: Nanjing Shizhou Biotechnology Co., Ltd
Tel: (+86)18013869214
Website: www.chemicalbook.com/ShowSupplierProductsList1514551/0.htm
Company Name: Wuhan ChemNorm Biotech Co.,Ltd.
Tel: +86-27-8439 4403 18971486879 , 18971486879
Website: www.chemnorm.com
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000 , +1-00000000000
Website: https://www.targetmol.com/
Tags:61276-17-3 Related Product Information
20633-67-4 20575-57-9 61276-17-3 81409-90-7 1914-99-4