| Identification | Back Directory | [Name]
4-Isobutyl-2-pyrrolidinone | [CAS]
61312-87-6 | [Synonyms]
Pregabalin Lactam
Pregabalin USP RC A
4-(2-Methylpropyl)-
Pregabalin impurity D
Pregabalin IMpurity IV
4-isobutyl-2-pyrrolidone
Pregabalin LactaM IMpurity
4-Isobutyl-2-pyrrolidinone
4-isobutylpyrrolidin-2-one
4-ISOBUTYL-2-PYRROLIDIN-1-YLNE
4-(2-Methylpropyl)-2-pyrrolidinone
4-(2-methylpropyl)pyrrolidin-2-one
2-pyrrolidinone, 4-(2-methylpropyl)-
4-isobutyl-2-pyrrolidinone(SALTDATA: FREE)
4-Isobutyl-2-pyrrolidinone (pregabalin lactaM iMpurity)
rac-Pregabalin EP Impurity A (Pregabalin Lactam Impurity) | [Molecular Formula]
C8H15NO | [MDL Number]
MFCD09864501 | [MOL File]
61312-87-6.mol | [Molecular Weight]
141.21 |
| Chemical Properties | Back Directory | [Boiling point ]
269.1±9.0 °C(Predicted) | [density ]
0.927±0.06 g/cm3(Predicted) | [storage temp. ]
Refrigerator | [solubility ]
Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
16.66±0.40(Predicted) | [color ]
Colourless to Light Yellow | [Major Application]
pharmaceutical | [InChI]
1S/C8H15NO/c1-6(2)3-7-4-8(10)9-5-7/h6-7H,3-5H2,1-2H3,(H,9,10) | [InChIKey]
GUGXRXLTTHFKHC-UHFFFAOYSA-N | [SMILES]
N1CC(CC1=O)CC(C)C | [CAS DataBase Reference]
61312-87-6 |
| Hazard Information | Back Directory | [Chemical Properties]
Pale Yellow Oil | [Uses]
Impurity in commercial preparation of Pregabalin. | [Uses]
Pregabalin (P704800) | [Uses]
Pregabalin intermediate | [Synthesis]
To 600 mL of methanol, 50.00 g of nitro compound (01), 18.04 g of NiCl2-6H2O was added; the solution was cooled down to 0°C-5°C and 18.2 g of sodium borohydride was added. After addition, the temperature was raised to 40°C-45°C and stirred for 12 hours. T | [References]
[1] Sripathi, S., Somesetti, N. R., Veeramalla, R., Challa, N. R., Peddi, S., Karnati, V. R. (2010). Synthesis and characterization of impurities of an anticonvulsant drug, Pregabalin. Arkivoc, 2010 1. https://doi.org/10.3998/ARK.5550190.0011.A22 |
|
|