| Identification | Back Directory | [Name]
6-(2-aMinophenoxy)benzo[d]isothiazol-3-aMine | [CAS]
613262-61-6 | [Synonyms]
M62812 free base
6-(2-aMinophenoxy)benzo[d]isothiazol-3-aMine | [Molecular Formula]
C13H11N3OS | [MDL Number]
MFCD21603930 | [MOL File]
613262-61-6.mol | [Molecular Weight]
257.311 |
| Hazard Information | Back Directory | [Uses]
M62812 (free base) is a toll-like receptor 4 (TLR4) signal transduction inhibitor. M62812 can suppress endothelial cell and leukocyte activation and prevents lethal septic shock in mice. M62812 can be used for the research of sepsis[1]. | [in vivo]
M62812 (i.v.; 10-20 mg/kg; single) protects mice from lethality and reduced inflammatory and coagulatory parameters in a murine d-galactosamine-sensitized endotoxin shock model[1].
M62812 (20 mg/kg/day) prevents mice from lethality in a murine cecal ligation and puncture model[1]. | Animal Model: | D-galactosamine-sensitized endotoxin shock mouse model[1] | | Dosage: | 10-20 mg/kg | | Administration: | Single intravenous administration | | Result: | Suppressed LPS-induced leukocyte and endothelial cell activation in vivo.
Prolonged survival in a d-galactosamine-sensitized endotoxin shock mouse model.
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| Animal Model: | A cecal ligation and puncture mouse model[1] | | Dosage: | 20 mg/kg | | Administration: | Intravenous administration; Everyday | | Result: | Reduced mortality in a murine cecal ligation and puncture model. |
| [References]
[1] Nakamura M, et al. Toll-like receptor 4 signal transduction inhibitor, M62812, suppresses endothelial cell and leukocyte activation and prevents lethal septic shock in mice. Eur J Pharmacol. 2007;569(3):237-243. DOI:10.1016/j.ejphar.2007.05.013 |
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