| Identification | Back Directory | [Name]
N1,N12-Diacetylspermine | [CAS]
61345-83-3 | [Synonyms]
N1,N12-Diacetylspermine
N,N'-Bis(3-acetylaminopropyl)-1,4-butanediamine
N-[3-[4-(3-acetamidopropylamino)butylamino]propyl]acetamide
Acetamide, N,N'-[1,4-butanediylbis(imino-3,1-propanediyl)]bis- | [Molecular Formula]
C14H30N4O2 | [MOL File]
61345-83-3.mol | [Molecular Weight]
286.41 |
| Chemical Properties | Back Directory | [storage temp. ]
2-8°C | [form ]
solid | [Major Application]
clinical testing | [InChI]
1S/C14H30N4O2/c1-13(19)17-11-5-9-15-7-3-4-8-16-10-6-12-18-14(2)20/h15-16H,3-12H2,1-2H3,(H,17,19)(H,18,20) | [InChIKey]
NPDTUDWGJMBVEP-UHFFFAOYSA-N | [SMILES]
N(CCCNC(=O)C)CCCCNCCCNC(=O)C |
| Hazard Information | Back Directory | [Uses]
N1,N12-Acetylspermine is a diacetylated derivative of spermine , an endogenous polyamine synthesized from spermidine , that displays lower Km and higher Vmax values than spermine, making it a better substrate of polyamine oxidase than the non-acetylated polyamine. Spermine is required for eukaryotic cell growth and protein synthesis and is involved in the modulation of calcium-dependent immune processes. Upregulation of N1,N12-acetylspermine has been linked to the incidence of cancer, making this natural polyamine a potential biomarker for cancer detection.[Cayman Chemical] | [Definition]
ChEBI:N(1),N(12)-diacetylspermine is an acetylspermine. It is a conjugate base of a N(1),N(12)-diacetylsperminium(2+). |
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