| Identification | Back Directory | [Name]
O-(4-hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine hydrochloride | [CAS]
6138-47-2 | [Synonyms]
Liotironina
Liothyronine HCl
3,3',5-Triiodo-L-thyronineHCl
3,3',5-Triiodo-L-thyroninehydrochloride
O-(4-hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine hydrochloride | [EINECS(EC#)]
228-120-0 | [Molecular Formula]
C15H13ClI3NO4 | [MOL File]
6138-47-2.mol | [Molecular Weight]
687.434 |
| Hazard Information | Back Directory | [Uses]
Liothyronine hydrochloride is an active form of thyroid hormone. Liothyronine hydrochloride is a potent thyroid hormone receptors TRα and TRβ agonist with Kis of 2.33 nM for hTRα and hTRβ, respectively[1][2][3]. | [References]
[1] Lin KH, et al. Stimulation of proliferation by 3,3',5-triiodo-L-thyronine in poorly differentiated human hepatocarcinoma cells overexpressing beta 1 thyroid hormone receptor. Cancer Lett. 1994 Oct 14;85(2):189-94. DOI:10.1016/0304-3835(94)90274-7
[2] Bhat MK, et al. Conformational changes of human beta 1 thyroid hormone receptor induced by binding of 3,3',5-triiodo-L-thyronine. Biochem Biophys Res Commun. 1993 Aug 31;195(1):385-92. DOI:10.1006/bbrc.1993.2055
[3] Hiroaki Shiohara, et al. Discovery of novel indane derivatives as liver-selective thyroid hormone receptor β (TRβ) agonists for the treatment of dyslipidemia. Bioorg Med Chem. 2012 Jun 1;20(11):3622-34. DOI:10.1016/j.bmc.2012.03.056 |
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