| Identification | Back Directory | [Name]
OXYTHIAMINE HYDROCHLORIDE | [CAS]
614-05-1 | [Synonyms]
OXYTHIAMINE HCL
OXYTHIAMINE HYDROCHLORIDE
Oxametholone Hydrochloride
OXYTHIAMINE CHLORIDE HYDROCHLORIDE
OXYTHIAMINE CHLORIDE HCL CRYSTALLINE
hydroxythiaminechloridehydrochloride
hyl)-4-methyl-,chloride,monohydrochloride
5-(2-HYDROXYETHYL)-3-(4-HYDROXY-2-METHYL-5-PYRIMIDINYLMETHYL)-4-METHYLTHIAZOLIUM CHLORIDE
5-[2-HYDROXYETHYL]-3-[4-HYDROXY-2-METHYL-5-PYRIMIDINYLMETHYL]-4-METHYLTHIAZOLIUM CHLORIDE HYDROCHLORIDE
5-[[5-(2-hydroxyethyl)-4-methyl-thiazol-3-ium-3-yl]methyl]-2-methyl-1H-pyrimidin-6-one chloride hydrochloride
5-[[5-(2-hydroxyethyl)-4-methyl-1,3-thiazol-3-ium-3-yl]methyl]-2-methyl-1H-pyrimidin-6-one chloride hydrochloride
5-(2-Hydroxyethyl)-4-methyl-3-[(2-methyl-6-oxo-1,6-dihydro-5-pyrimidinyl)methyl]-1,3-thiazol-3-ium chloride hydrochloride (1:1:1) | [Molecular Formula]
C12H17Cl2N3O2S | [MDL Number]
MFCD00050656 | [MOL File]
614-05-1.mol | [Molecular Weight]
338.25 |
| Chemical Properties | Back Directory | [Melting point ]
>190°C (subl.) | [storage temp. ]
−20°C
| [solubility ]
DMSO (Slightly, Heated), Methanol (Slightly), Water (Slightly) | [form ]
Solid | [color ]
White to Off-White | [Stability:]
Hygroscopic | [InChI]
1S/C12H16N3O2S.2ClH/c1-8-11(3-4-16)18-7-15(8)6-10-5-13-9(2)14-12(10)17;;/h5,7,16H,3-4,6H2,1-2H3,(H,13,14,17);2*1H | [InChIKey]
QHUYPZVMEJLSEB-UHFFFAOYSA-N | [SMILES]
CC(N1)=NC=C(C[N+]2=CSC(CCO)=C2C)C1=O.Cl.[Cl-] |
| Hazard Information | Back Directory | [Uses]
thiamine antagonist | [Definition]
ChEBI: A hydrochloride obtained by combining oxythiamine chloride with one molar equivalent of hydrochloric acid. | [General Description]
Oxythiamine is a thiamine antimetabolite and the source through diet is by consuming acidic thiamine rich foods. | [Biochem/physiol Actions]
Oxythiamine (OT) is a thiamine antagonist. It is a transketolase inhibitor and is employed to study anti-metastatic mechanisms, especially those involving metalloproteinases (MMP). It significantly sensitizes human hepatocellular carcinoma cells (HCC) to sorafenib, favoring tumor suppression. | [in vivo]
Oxythiamine chloride hydrochloride (100-500 mg/kg, i.p. 4 days) inhibits tumor growth in Ehrlich's ascites tumor hosting mice[2].
Oxythiamine chloride hydrochloride (250 or 500 mg/kg, daily for 5 week) inhibits tumor cell metastasis via inhibition of MMPs in mice implanted (s.c.) with LLC cells[4].
| Animal Model: | Ehrlich's ascites tumor hosting mice[2] | | Dosage: | 100-500 mg/kg | | Administration: | i.p., 4 days | | Result: | Inhibited tumor growth by 43% at 300 mg/kg and 84% at 500 mg/kg. |
| [storage]
Store at -20°C |
|
| Company Name: |
Spectrum Chemical Manufacturing Corp.
|
| Tel: |
021-021-021-67601398-809-809-809 15221380277 |
| Website: |
www.spectrumchemical.com/oa_html/index.jsp?minisite=10020&respid=22372&language=us |
| Company Name: |
Sigma-Aldrich
|
| Tel: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
|