| Identification | More | [Name]
2-Acetamidophenol | [CAS]
614-80-2 | [Synonyms]
2-ACETAMIDOPHENOL
2-ACETAMINO PHENOL
2-ACETYLAMINOPHENOL
2'-HYDROXYACETANILIDE
2-HYDROXYACETANILIDE
AKOS BBB/377
N-(2-Hydroxyphenyl)acetamide
O-ACETAMIDOPHENOL
O-ACETAMINOPHENOL
O-HYDROXYACETANILIDE
2’-hydroxy-acetanilid
2-acetamido-pheno
2-Hydroxyanilid kyseliny octove
2-hydroxyanilidkyselinyoctove
Acetanilide, 2'-hydroxy-
Acet-o-aminofenol
n-(2-hydroxyphenyl)-acetamid
N-(2-hydroxyphenyl)ethanamide
N-Acetyl-2-aminophenol
N-Acetyl-o-aminophenol | [EINECS(EC#)]
210-396-9 | [Molecular Formula]
C8H9NO2 | [MDL Number]
MFCD00002181 | [Molecular Weight]
151.16 | [MOL File]
614-80-2.mol |
| Chemical Properties | Back Directory | [Appearance]
light brown powder | [Melting point ]
205-210 °C(lit.) | [Boiling point ]
273.17°C (rough estimate) | [density ]
1.2023 (rough estimate) | [refractive index ]
1.5810 (estimate) | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Powder | [pka]
9.35±0.35(Predicted) | [color ]
Off-white to beige to brown | [Stability:]
Stable. Incompatible with strong oxidizing agents, chloroformates, acids, acid chlorides, acid anhydrides. | [BRN ]
607592 | [CAS DataBase Reference]
614-80-2(CAS DataBase Reference) | [NIST Chemistry Reference]
Acetamide, N-(2-hydroxyphenyl)-(614-80-2) | [Storage Precautions]
Air sensitive;Light sensitive;Moisture sensitive | [EPA Substance Registry System]
614-80-2(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi,Xn | [Risk Statements ]
R36/38:Irritating to eyes and skin .
R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S37/39:Wear suitable gloves and eye/face protection . | [RIDADR ]
2811 | [WGK Germany ]
3
| [RTECS ]
AE4025000
| [F ]
1-8 | [TSCA ]
Yes | [HazardClass ]
6.1(b) | [PackingGroup ]
III | [HS Code ]
29242990 |
| Hazard Information | Back Directory | [Chemical Properties]
light brown powder | [Uses]
An Acetaminophen (A161220) impurity.
2-Acetamidophenol is used as raw material to manufacture industrial organic chemicals.
Acetaminophen is an analgesic and antipyretic agent and used as a pain reliever to treat headache, muscle aches, and arthritis. | [Definition]
ChEBI: 2-acetamidophenol is a member of the class of phenols that is 2-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group. A positional isomer of paracetamol which possesses anti-inflammatory, anti-arthritic and anti-platelet aggregation properties. It has a role as a platelet aggregation inhibitor, an anti-inflammatory agent, a xenobiotic metabolite, an apoptosis inducer, an antineoplastic agent and an antirheumatic drug. It is a member of phenols and a member of acetamides. | [Preparation]
Mix 2-Aminophenol , acetic acid and Acetic anhydride (i.e., crystals appear), and then directly heated on the fire until all dissolved, stop heating, cooling, water dilution, precipitation of crystals filtered dry, to 70-80 ℃ of ethanol recrystallization to obtain 2-acetamidophenol. | [General Description]
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. | [storage]
Store at -20°C | [Purification Methods]
Recrystallise it from water, EtOH or Est aqueous EtOH. [Beilstein 13 H 370, 13 I 113, 13 II 171, 13 III 778.] |
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