ChemicalBook--->CAS DataBase List--->614-80-2

614-80-2

614-80-2 Structure

614-80-2 Structure
IdentificationMore
[Name]

2-Acetamidophenol
[CAS]

614-80-2
[Synonyms]

2-ACETAMIDOPHENOL
2-ACETAMINO PHENOL
2-ACETYLAMINOPHENOL
2'-HYDROXYACETANILIDE
2-HYDROXYACETANILIDE
AKOS BBB/377
N-(2-Hydroxyphenyl)acetamide
O-ACETAMIDOPHENOL
O-ACETAMINOPHENOL
O-HYDROXYACETANILIDE
2’-hydroxy-acetanilid
2-acetamido-pheno
2-Hydroxyanilid kyseliny octove
2-hydroxyanilidkyselinyoctove
Acetanilide, 2'-hydroxy-
Acet-o-aminofenol
n-(2-hydroxyphenyl)-acetamid
N-(2-hydroxyphenyl)ethanamide
N-Acetyl-2-aminophenol
N-Acetyl-o-aminophenol
[EINECS(EC#)]

210-396-9
[Molecular Formula]

C8H9NO2
[MDL Number]

MFCD00002181
[Molecular Weight]

151.16
[MOL File]

614-80-2.mol
Chemical PropertiesBack Directory
[Appearance]

light brown powder
[Melting point ]

205-210 °C(lit.)
[Boiling point ]

273.17°C (rough estimate)
[density ]

1.2023 (rough estimate)
[refractive index ]

1.5810 (estimate)
[storage temp. ]

Keep in dark place,Inert atmosphere,Room temperature
[solubility ]

DMSO (Slightly), Methanol (Slightly)
[form ]

Powder
[pka]

9.35±0.35(Predicted)
[color ]

Off-white to beige to brown
[Stability:]

Stable. Incompatible with strong oxidizing agents, chloroformates, acids, acid chlorides, acid anhydrides.
[BRN ]

607592
[InChI]

InChI=1S/C8H9NO2/c1-6(10)9-7-4-2-3-5-8(7)11/h2-5,11H,1H3,(H,9,10)
[InChIKey]

ADVGKWPZRIDURE-UHFFFAOYSA-N
[SMILES]

C(NC1=CC=CC=C1O)(=O)C
[CAS DataBase Reference]

614-80-2(CAS DataBase Reference)
[NIST Chemistry Reference]

Acetamide, N-(2-hydroxyphenyl)-(614-80-2)
[Storage Precautions]

Air sensitive;Light sensitive;Moisture sensitive
[EPA Substance Registry System]

614-80-2(EPA Substance)
Safety DataBack Directory
[Symbol(GHS) ]

Exclamation Mark (GHS07)
GHS07
[Signal word ]

Warning
[Hazard statements ]

H315-H319-H335
[Precautionary statements ]

P261-P280a-P304+P340-P305+P351+P338-P405-P501a-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313
[Hazard Codes ]

Xi,Xn
[Risk Statements ]

R36/38:Irritating to eyes and skin .
R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin .
[Safety Statements ]

S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S37/39:Wear suitable gloves and eye/face protection .
[RIDADR ]

2811
[WGK Germany ]

3
[RTECS ]

AE4025000
[F ]

1-8
[TSCA ]

Yes
[HazardClass ]

6.1(b)
[PackingGroup ]

III
[HS Code ]

29242990
Raw materials And Preparation ProductsBack Directory
[Raw materials]

2-Aminophenol-->Acetic anhydride
[Preparation Products]

4-Bromo-2-hydroxybenzoic acid-->2-Methylbenzoxazole-->6-Bromo-2H-1,4-benzoxazin-3(4H)-one-->N-(2-Butyloxyphenyl)acetamide-->Dimethyl 2-(4-methoxybenzyl)malonate
Hazard InformationBack Directory
[Chemical Properties]

light brown powder
[Uses]

An Acetaminophen (A161220) impurity.
2-Acetamidophenol is used as raw material to manufacture industrial organic chemicals.
Acetaminophen is an analgesic and antipyretic agent and used as a pain reliever to treat headache, muscle aches,  and arthritis.
[Definition]

ChEBI: 2-acetamidophenol is a member of the class of phenols that is 2-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group. A positional isomer of paracetamol which possesses anti-inflammatory, anti-arthritic and anti-platelet aggregation properties. It has a role as a platelet aggregation inhibitor, an anti-inflammatory agent, a xenobiotic metabolite, an apoptosis inducer, an antineoplastic agent and an antirheumatic drug. It is a member of phenols and a member of acetamides.
[Preparation]

Mix 2-Aminophenol , acetic acid and Acetic anhydride (i.e., crystals appear), and then directly heated on the fire until all dissolved, stop heating, cooling, water dilution, precipitation of crystals filtered dry, to 70-80 ℃ of ethanol recrystallization to obtain 2-acetamidophenol.
[General Description]

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
[storage]

Store at -20°C
[Purification Methods]

Recrystallise it from water, EtOH or Est aqueous EtOH. [Beilstein 13 H 370, 13 I 113, 13 II 171, 13 III 778.]
Spectrum DetailBack Directory
[Spectrum Detail]

2-Acetamidophenol(614-80-2)MS
2-Acetamidophenol(614-80-2)1HNMR
2-Acetamidophenol(614-80-2)IR1
2-Acetamidophenol(614-80-2)IR2
2-Acetamidophenol(614-80-2)Raman
Well-known Reagent Company Product InformationBack Directory
[Acros Organics]

2-Acetamidophenol, 97%(614-80-2)
[Alfa Aesar]

2-Acetamidophenol, 97%(614-80-2)
[Sigma Aldrich]

614-80-2(sigmaaldrich)
[TCI AMERICA]

2'-Hydroxyacetanilide,>99.0%(T)(614-80-2)
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