| Identification | Back Directory | [Name]
4-[4-phenyl-6-(trifluoromethyl)pyrimidin-2-yl]morpholine | [CAS]
615273-95-5 | [Synonyms]
WAY-327111
EP2 receptor antagonist-2
4-[4-phenyl-6-(trifluoromethyl)pyrimidin-2-yl]morpholine
Morpholine, 4-[4-phenyl-6-(trifluoromethyl)-2-pyrimidinyl]- | [Molecular Formula]
C15H14F3N3O | [MOL File]
615273-95-5.mol | [Molecular Weight]
309.29 |
| Chemical Properties | Back Directory | [Boiling point ]
451.8±55.0 °C(Predicted) | [density ]
1.299±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
1.48±0.50(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
EP2 receptor antagonist-2 (CID891729) is an antagonist of EP2 receptor. EP2 receptor antagonist-2 inhibits the EP2 receptor activation induced by PGE2. EP2 receptor antagonist-2 also suppresses lactate dehydrogenase (LDH) release induced by N-methyl-D-aspartate (NMDA)[1]. | [IC 50]
EP | [References]
[1] Jiang J, et al. Discovery of 2-Piperidinyl Phenyl Benzamides and Trisubstituted Pyrimidines as Positive Allosteric Modulators of the Prostaglandin Receptor EP2. ACS Chem Neurosci. 2018 Apr 18;9(4):699-707. DOI:10.1021/acschemneuro.7b00486 |
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| Company Name: |
OTAVA chemicals
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| Tel: |
416 305 9979 (Canada) |
| Website: |
www.otavachemicals.com |
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