| Identification | Back Directory | [Name]
15-keto Prostaglandin A1 | [CAS]
61600-67-7 | [Synonyms]
15-keto PGA1
15-keto Prostaglandin A1
Prosta-10,13-dien-1-oic acid, 9,15-dioxo-, (13E)- (9CI) | [Molecular Formula]
C20H30O4 | [MOL File]
61600-67-7.mol | [Molecular Weight]
334.45 |
| Hazard Information | Back Directory | [Description]
Prostaglandin A1 (PGA1) was first isolated as a dehydration product of the PGE1 compounds found in human semen. 15-keto PGA1 is a metabolite of PGA1, produced by 15-hydroxy PG dehydrogenase. It can be produced from PGA1 in pig lung, trachea, aorta, and pulmonary artery tissue preparations. 15-keto PGA1, given at a concentration of 6 μM, causes vasoconstriction of rabbit lung that is comparable to that induced by angiotensin II. | [Uses]
15-keto PGA1 is a metabolite of PGA1 (P838545), produced by 15-hydroxy PG dehydrogenase. | [Definition]
ChEBI: 15-dehydroprostaglandin A1 is a member of the class of prostaglandins A obtained by oxidation of the 15-hydroxy group of prostaglandin A1 to the corresponding ketone. It has a role as an Escherichia coli metabolite and a human metabolite. It is functionally related to a prostaglandin A1. It is a conjugate acid of a 15-dehydroprostaglandin A1(1-). | [References]
[1] MATS HAMBERG B S. Prostaglandins of human seminal plasma.[J]. The Blue sheet, 1963, 89 1: 34. DOI: 10.1016/s0021-9258(18)96910-3
[2] C ODY. PGA1 and PGF2 alpha metabolism by pig pulmonary endothelium, smooth muscle, and fibroblasts.[J]. Journal of applied physiology: respiratory, environmental and exercise physiology, 1979, 46 2: 211-216. DOI: 10.1152/jappl.1979.46.2.211
[3] KENNETH B. GROSS C. N G. Comparison of the pulmonary vascular response to prostaglandin A1, prostaglandin F2α and angiotensin II; Metabolism of PGA1 in lung[J]. Life sciences, 1976, 19 11: Pages 1653-1661. DOI: 10.1016/0024-3205(76)90070-9 |
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