| Identification | More | [Name]
HYOSCYAMINE SULFATE | [CAS]
620-61-1 | [Synonyms]
(-)-HYOSCYAMINE SULFATE
HYOSCYAMINE SULFATE
L-HYOSCYAMINE SULFATE
L-HYOSCYAMINE SULFATE HEMISULFATE SALT
L-TROPINE TROPATE SULFATE
[3(s)-endo]-lestesulfate(2:1)(salt)
1-alpha-h,5-alpha-h-tropan-3-alpha-ol,(-)-tropate(ester),sulfate(2:1)
egazil
levsinsulfate
Hyoscyamine sulfate hydrate
L-Hyoscyamine Hemisulfate
HYOSCYAMINESULFATE(ANHYDROUS)
Benzeneacetic acid, α-(hydroxymethyl)-, (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester, (αS)-, sulfate (2:1) (salt)
Benzeneacetic acid, α-(hydroxymethyl)-, 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester, [3(S)-endo]-, sulfate (2:1) (salt)
Hyoscyamine sulfate (2:1)
Hyoscyamine sulfate (2:1) (salt)
NuLev
Hyoscyaminsulfat
Hyoscyamine sulfuric acid | [EINECS(EC#)]
210-644-6 | [Molecular Formula]
C34H48N2O10S | [MDL Number]
MFCD00078244 | [Molecular Weight]
676.82 | [MOL File]
620-61-1.mol |
| Safety Data | Back Directory | [Risk Statements ]
R26/28:Very Toxic by inhalation and if swallowed . | [Safety Statements ]
S1:Keep locked up .
S24/25:Avoid contact with skin and eyes .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . | [RTECS ]
YM6107000 | [TSCA ]
TSCA listed |
| Hazard Information | Back Directory | [Uses]
L-Hyoscyamine sulfate (Daturine sulfate), a natural plant tropane alkaloid, is a potent and competitive muscarinic receptor (MR) antagonist. L-Hyoscyamine sulfate is a levo-isomer to Atropine (HY-B1205)[1][2]. | [General Description]
Hyoscyamine sulfate(Levsin sulfate) is a white, odorless, crystalline compoundof a deliquescent nature that also is affected by light. It issoluble in water (1:0.5) and alcohol (1:5) but almost insolublein ether. Solutions of hyoscyamine sulfate are acidicto litmus. | [Clinical Use]
Hyoscyamine sulfate is used as an anticholinergic in the same mannerand for the same indications as atropine and hyoscyamine, butit possesses the disadvantage of being deliquescent. | [in vivo]
L-Hyoscyamine sulfate (Daturine sulfate; 5-20 mg/kg; iv) prolongs the migrating MMC cycle length[1]. | Animal Model: | Rats[1] | | Dosage: | 5, 10, 20 mg/kg | | Administration: | IV | | Result: | Prolonged the migrating myoelectric complex (MMC) cycle length.
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| [References]
[1] Lars G?ran Axelsson, et al. Regulatory role of 5-HT and muscarinic receptor antagonists on the migrating myoelectric complex in rats. Eur J Pharmacol. 2003 Apr 25;467(1-3):211-8. DOI:10.1016/s0014-2999(03)01637-6
[2] Harald John, et al. Application of an enantioselective LC-ESI MS/MS procedure to determine R- and S-hyoscyamine following intravenous atropine administration in swine. Drug Test Anal. Mar-Apr 2012;4(3-4):194-8. DOI:10.1002/dta.338 |
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