| Identification | Back Directory | [Name]
THS-044 | [CAS]
62054-67-5 | [Synonyms]
THS-044
THS044;THS 044
4-Morpholinamine, N-[2-nitro-4-(trifluoromethyl)phenyl]- | [EINECS(EC#)]
610-261-8 | [Molecular Formula]
C11H12F3N3O3 | [MOL File]
62054-67-5.mol | [Molecular Weight]
291.23 |
| Chemical Properties | Back Directory | [Melting point ]
106-108 °C | [Boiling point ]
347.1±52.0 °C(Predicted) | [density ]
1.464±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
-0.19±0.50(Predicted) | [color ]
Yellow to orange |
| Hazard Information | Back Directory | [Uses]
THS-044 binding stabilizes the HIF2α PAS-B folded state, for regulating HIF2 activity in endogenous and clinical settings.
Target: HIF2α
Limited trypsin proteolysis reveals that both apo and THS-044-bound protein are efficiently cut at R330 in the extended HI loop. In the THS-044 bound state, there appears no additional proteolysis at the remaining candidate trypsin sites. In contrast, these THS-044-protected sites are protease accessible in the unliganded protein, leading its complete degradation. In parallel, NMR-based deuterium exchange measurements revealed a dramatic stabilization of the THS-044-bound protein β-sheet, with some sites experiencing 100-fold enhanced protection factors relative to the ligand-free protein. | [storage]
Store at -20°C | [References]
[1] Motto I, et al. New aryl hydrocarbon receptor homology model targeted to improve docking reliability. J Chem Inf Model. 2011 Nov 28;51(11):2868-2881. DOI:10.1021/ci2001617
[2] Scheuermann TH, et al. Artificial ligand binding within the HIF2alpha PAS-B domain of the HIF2 transcription factor. Proc Natl Acad Sci U S A. 2009 Jan 13;106(2):450-455. DOI:10.1073/pnas.0808092106 |
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| Company Name: |
Musechem
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| Tel: |
+1-800-259-7612 |
| Website: |
www.musechem.com |
| Company Name: |
Twochem Co.Ltd.
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| Tel: |
021-58111628 15800915896 |
| Website: |
cn.twochem.com |
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