| Identification | Back Directory | [Name]
(-)-Syringaresinol | [CAS]
6216-81-5 | [Synonyms]
Phenol, 4,4'-[(1R,3aS,4R,6aS)-tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diyl]bis[2,6-dimethoxy- | [Molecular Formula]
C22H26O8 | [MDL Number]
MFCD28386003 | [MOL File]
6216-81-5.mol | [Molecular Weight]
418.44 |
| Hazard Information | Back Directory | [Uses]
(-)-Syringaresinol, is the isoform of Syringaresinol (HY-N8307), which can be found in stems of Annona Montana, possesses anti-cancer activity. Syringaresinol is an activator of NO synthase phosphorylation and induces vasodilation. Syringaresinol also inhibits the NF-κB pathway and exerts anti-inflammatory activity[1][2][3]. | [Definition]
ChEBI: (-)-syringaresinol is the (7beta,7'beta,8beta,8'beta)-stereoisomer of syringaresinol. It is an enantiomer of a (+)-syringaresinol. | [References]
[1] Chung BH, et al. Syringaresinol causes vasorelaxation by elevating nitric oxide production through the phosphorylation and dimerization of endothelial nitric oxide synthase. Exp Mol Med. 2012 Mar 31;44(3):191-201. DOI:10.3858/emm.2012.44.3.014
[2] Wang X, et al. Syringaresinol attenuates osteoarthritis via regulating the NF-κB pathway. Int Immunopharmacol. 2023 May;118:109982. DOI:10.1016/j.intimp.2023.109982
[3] Y C Wu, et al. Bioactive constitutents from the stems of Annona Montana. Planta Med. 1995 Apr;61(2):146-9. DOI:10.1055/s-2006-958035 |
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