| Identification | Back Directory | [Name]
7-AMINO-4-CHLORO-3-METHOXYISOCOUMARIN | [CAS]
62252-26-0 | [Synonyms]
JLK6
JCP 251)
JCP251
(JCP-251
GAMMA-SECRETASE INHIBITOR XI
7-AMINO-4-CHLORO-3-METHOXYISOCOUMARIN
7-Amino-4-chloro-3-methoxy-1H-2-benzopyran
7-Amino-4-chloro-3-methoxy-isochromen-1-one
7-Amino-4-chloro-3-methoxy-1H-isochromen-1-one
1H-2-Benzopyran-1-one, 7-amino-4-chloro-3-methoxy- | [Molecular Formula]
C10H8ClNO3 | [MDL Number]
MFCD04035584 | [MOL File]
62252-26-0.mol | [Molecular Weight]
225.63 |
| Chemical Properties | Back Directory | [Melting point ]
115 °C | [Boiling point ]
456.1±45.0 °C(Predicted) | [density ]
1.46±0.1 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Sealed in dry,2-8°C | [solubility ]
DMSO (Slightly) | [form ]
Solid | [pka]
1.95±0.20(Predicted) | [color ]
Yellow to Beige | [Stability:]
Hygroscopic |
| Hazard Information | Back Directory | [Uses]
JLK 6 is an inhibitor of γ-secretase, selectively inhibits βAPP cleavage. | [Definition]
ChEBI: 7-amino-4-chloro-3-methoxy-2-benzopyran-1-one is a member of isocoumarins. | [Biological Activity]
Inhibitor of γ -secretase that selectively inhibits β APP cleavage without affecting other γ -secretase-mediated pathways. Prevents recovery of A β 40 and A β 42 from HEK293 cell overexpressing wild-type or Swedish-mutated β APP (IC 50 ~ 30 μ M) but displays no effect on Notch cleavage and Notch-mediated intracellular signaling. Displays no activity on BACE1, BACE2, α -secretase, the proteosome or GSK3 β . | [References]
[1]. petit a, pasini a, alves da costa c, et al. jlk isocoumarin inhibitors: selective γ-secretase inhibitors that do not interfere with notch pathway in vitro or in vivo. journal of neuroscience research, 2003, 74(3): 370-377.
[2]. petit a, bihel f, da costa ca, et al. new protease inhibitors prevent γ-secretase-mediated production of aβ40/42 without affecting notch cleavage. nature cell biology, 2001, 3(5): 507-511. |
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