| Identification | Back Directory | [Name]
Wee1 Inhibitor | [CAS]
622855-37-2 | [Synonyms]
WEE1-IN-4
Wee1 Inhibitor
Pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione, 4-(2-chlorophenyl)-9-hydroxy- | [Molecular Formula]
C20H11ClN2O3 | [MOL File]
622855-37-2.mol | [Molecular Weight]
362.77 |
| Chemical Properties | Back Directory | [storage temp. ]
-20°C | [solubility ]
DMSO: 10 mg/ml,Ethanol: 10 mg/ml | [form ]
A solid | [color ]
Yellow to orange | [InChI]
1S/C20H11ClN2O3/c21-13-4-2-1-3-10(13)11-8-15-16(18-17(11)19(25)23-20(18)26)12-7-9(24)5-6-14(12)22-15/h1-8,22,24H,(H,23,25,26) | [InChIKey]
DPEXRCOBPACFOO-UHFFFAOYSA-N | [SMILES]
Clc1c(cccc1)c2c3c(c4c([nH]c5c4cc(cc5)O)c2)[c]([nH][c]3=O)=O |
| Hazard Information | Back Directory | [Uses]
WEE1-IN-4 (Compound 15) is a potent checkpoint Wee1 kinase inhibitor with an IC50 of 0.011 μM. Wee1 inhibitors can abrogate the G2/M checkpoint[1]. | [Biological Activity]
Wee1 inhibitor is an inhibitor of the checkpoint kinase Wee1 (IC50 = 11 nM).1 It is selective for Wee1 over checkpoint kinase 1 (Chk1; IC50 = 440 nM). Wee1 inhibitor also inhibits the ATPase activity of LptB, an enzyme involved in the transport and assembly of LPS (IC50 = 25 μM for the E. coli enzyme).2 | [References]
1.Palmer, B.D., Thompson, A.M., Booth, R.J., et al.4-Phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione inhibitors of the checkpoint kinase Wee1. Structure-activity relationships for chromophore modification and phenyl ring substitutionJ. Med. Chem.49(16)4896-4911(2006)
2.Gronenberg, L.S., and Kahne, D.Development of an activity assay for discovery of inhibitors of lipopolysaccharide transportJ. Am. Chem. Soc.132(8)2518-2519(2010)
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