| Identification | Back Directory | [Name]
N-pyridin-3-ylthiophene-2-carboxamide | [CAS]
62289-81-0 | [Synonyms]
SW-106065
N-pyridin-3-ylthiophene-2-carboxamide
2-Thiophenecarboxamide, N-3-pyridinyl- | [Molecular Formula]
C10H8N2OS | [MDL Number]
MFCD00469725 | [MOL File]
62289-81-0.mol | [Molecular Weight]
204.25 |
| Chemical Properties | Back Directory | [Boiling point ]
270.8±15.0 °C(Predicted) | [density ]
1.352±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 100 mg/mL (489.60 mM) | [form ]
Solid | [pka]
12.39±0.70(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
SW106065 is an apoptosis inducer in malignant peripheral nerve sheath tumors (MPNST). SW106065 inhibits ATP consumption of sMPNST and other models of MPNST with an EC50 of 1 μM. SW106065 can be used for MPNST research[1]. | [Biological Activity]
Cell permeable: yes''Reversible: yes | [in vivo]
SW106065 (Cpd21; 40 mg/kg; intraperitoneal injection; twice per day for 4 weeks) treatment can be delivered to mice in concentrations to sufficiently penetrate sMPNST tissue, and inhibit tumor development[1]. | Animal Model: | NCR-nu/nu female mice (6-7 week old) injected with MPNST cells[1] | | Dosage: | 40 mg/kg | | Administration: | Intraperitoneal injection; twice per day for 4 weeks | | Result: | Reduced MPNST burden in a mouse allograft model.
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| [storage]
Store at -20°C | [References]
[1] Vincent Chau, et al. Preclinical therapeutic efficacy of a novel pharmacologic inducer of apoptosis in malignant peripheral nerve sheath tumors. Cancer Res. 2014 Jan 15;74(2):586-97. DOI:10.1158/0008-5472.CAN-13-1934 |
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| Company Name: |
InvivoChem
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| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
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