| Identification | Back Directory | [Name]
H-D-PRO-PHE-ARG-PNA 2 HCL | [CAS]
62354-56-7 | [Synonyms]
pFR-pNA
H-D-PRO-PHE-ARG-PNA 2 HCL
D-Pro-Phe-Arg-pNA (hydrochloride)
D-pro-phe-arg P-nitroanilide*dihydrochloride
L-Argininamide,D-prolyl-L-phenylalanyl-N-(4-nitrophenyl)-,dihydrochloride | [Molecular Formula]
C26H36Cl2N8O5 | [MDL Number]
MFCD00274447 | [MOL File]
62354-56-7.mol | [Molecular Weight]
611.52 |
| Hazard Information | Back Directory | [Description]
D-Pro-Phe-Arg-pNA is a colorimetric substrate for plasma kallikrein. Plasma kallikrein preferentially binds to and cleaves the D-Pro-Phe-Arg (PFR) peptide sequence to release p-nitroanilide (pNA), which can be quantified by colorimetric detection at 405 nm as a measure of plasma kallikrein activity. | [Uses]
D-Pro-Phe-Arg-pNA hydrochloride is the substrate for thrombin-like enzyme, with Km of 50.7 μM[1]. | [References]
[1] Magalh?es HP, et al., Mechanism of action and determination of the best substrate for a thrombin-like enzyme from Lachesis muta muta venom by regression analysis of the kinetic parameters determined with peptidyl p-nitroanilide substrates. Toxicon. 2006 Mar 15;47(4):453-8. DOI:10.1016/j.toxicon.2006.01.001 |
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