| Identification | More | [Name]
4'-CHLORO-5-FLUORO-2-HYDROXYBENZOPHENONE | [CAS]
62433-26-5 | [Synonyms]
4'-CHLORO-5-FLUORO-2-HYDROXYBENZOPHENONE
4-CHLORO-5'-FLUORO-2'-HYDROXYBENZOPHENONE
METHANONE, (4-CHLOROPHENYL)(5-FLUORO-2-HYDROXYPHENYL)-
4'-CHLORO-5-FLUORO-2-HYDROXYBENZOPHENON&
4'-Chloro-5-fluoro-2-hydroxybenzophenone97%
(4-Chlorophenyl)(5-fluoro-2-hydroxyphenyl) ketone
2-Hydroxy-4'-chloro-5-fluorobenzophenone
SL-79-182
SL-79-182-00 | [EINECS(EC#)]
263-539-2 | [Molecular Formula]
C13H8ClFO2 | [MDL Number]
MFCD00040948 | [Molecular Weight]
250.65 | [MOL File]
62433-26-5.mol |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [Hazard Note ]
Irritant | [HS Code ]
2914500090 |
| Hazard Information | Back Directory | [Uses]
4''-Chloro-5-fluoro-2-hydroxybenzophenone is a metabolite of Progabide (P755350) which is a gamma-aminobutyric acid (GABA) antagonist with antiepileptic activity. 4''-Chloro-5-fluoro-2-hydroxybenzophenone is also used as a reagent in the synthesis of a series of novel dihydrobenzofuranols which displayed antibacterial activity comparable to bacitracin, ciprofloxacin and gentamicin. | [Preparation]
Preparation by Fries rearrangement of p-fluorophenyl p-chlorobenzoate,
? with titanium tetrachloride at 150° for 18 h (81%);
? with aluminium chloride, at 130° for 2 h (98%) or at 200° for 5 min or for 15 min (65%). |
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