| Identification | Back Directory | [Name]
R 1440 | [CAS]
625114-41-2 | [Synonyms]
R 1440
RO 4389620
Piragliatin
RO4389620; RO 4389620; R 1440; R-1440
2-(3-Chloro-4-(methylsulfonyl)phenyl)-3-((S)-3-oxocyclopentyl)-N-(pyrazin-2-yl)propanamide
(2R)-2-(3-chloro-4-methylsulfonylphenyl)-3-[(1R)-3-oxocyclopentyl]-N-pyrazin-2-ylpropanamide
Benzeneacetamide, 3-chloro-4-(methylsulfonyl)-α-[[(1R)-3-oxocyclopentyl]methyl]-N-2-pyrazinyl-, (αR)- | [Molecular Formula]
C19H20ClN3O4S | [MDL Number]
MFCD19443694 | [MOL File]
625114-41-2.mol | [Molecular Weight]
421.91 |
| Hazard Information | Back Directory | [Uses]
Piragliatin (RO4389620) is an activator for glucokinase, which reduces endogenous glucose production, increases β-cell function and glucose utilization, and thus decreases the blood glucose levels. Piragliatin exhibits antidiabetic efficacy[1]. | [References]
[1] Bonadonna RC, et al., Piragliatin (RO4389620), a novel glucokinase activator, lowers plasma glucose both in the postabsorptive state and after a glucose challenge in patients with type 2 diabetes mellitus: a mechanistic study. J Clin Endocrinol Metab. 2010 Nov;95(11):5028-36. DOI:10.1210/jc.2010-1041 |
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