| Identification | Back Directory | [Name]
DSIP | [CAS]
62568-57-4 | [Synonyms]
DSIP
DSIP 4H2O
WAGGDASGE
EMIDELTIDE
Delta-Sleep
DSIP acetate
Etipolypeptide
DSIP USP/EP/BP
Ftpp/Adipotide
DSIP, EMideltide
DSIP nonapeptide
SLEEP INDUCING PEPTIDE
DSIP Lyophilized Powder
DELTA SLEEP INDUCING PEPTIDE
DELTA SLEEP-INDUCING PEPTIDE 4H2O
DSIP/Delta Sleep Inducing Peptide
TRP-ALA-GLY-GLY-ASN-ALA-SER-GLY-GLU
TRP-ALA-GLY-GLY-ASP-ALA-SER-GLY-GLU
Deltasleep-inducing peptide (rabbit)
Emideltide (δ-Sleep Inducing Peptide)
Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu-OH
TRP-ALA-GLY-GLY-ASP-ALA-SER-GLY-GLU 4H2O
H-TRP-ALA-GLY-GLY-ASP-ALA-SER-GLY-GLU-OH
Delta sleep inducing peptide, ≥97% (HPLC)
L-Trp-L-Ala-Gly-Gly-L-Asp-L-Ala-L-Ser-Gly-Glu-OH
L-Trp-L-Ala-Gly-Gly-L-Asp-L-Ala-L-Ser-Gly-L-Glu-OH
TRP-ALA---ASP-ALA-SER--GLU(TRP-ALA-GLY-GLY-ASP-ALA-SER-GLY-GLU)
TRP-ALA-GLY-GLY-ASP-ALA-SER: PO3H2-GLY-GLU [WAGGDA-S: PO3H2-GE]
DSIP, Sleep inducing peptide, Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu
L-Tryptophyl-L-alanylglycylglycyl-L-alpha-aspartyl-L-alanyl-L-serylglycyl-L-glutamic acid
Delta-Sleep Inducing Peptide trifluoroacetate salt H-Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu-OH trifluoroacetate salt | [EINECS(EC#)]
211-519-9 | [Molecular Formula]
C35H48N10O15 | [MDL Number]
MFCD00076883 | [MOL File]
62568-57-4.mol | [Molecular Weight]
848.81 |
| Chemical Properties | Back Directory | [Boiling point ]
1522.7±65.0 °C(Predicted) | [density ]
1.458±0.06 g/cm3(Predicted) | [storage temp. ]
−20°C
| [form ]
Powder | [pka]
3.18±0.10(Predicted) | [color ]
White to off-white | [Water Solubility ]
Soluble in water at 0.5mg/ml | [Sequence]
H-Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu-OH | [InChIKey]
ZRZROXNBKJAOKB-GFVHOAGBSA-N |
| Hazard Information | Back Directory | [Description]
Delta-sleep-inducing peptide (DSIP) is a neuropeptide with amino acid sequence Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu and molecular mass 848.81 g/mol. DSIP occurs in both free and bound forms in the hypothalamus, limbic system and pituitary as well as various peripheral organs, tissues and body fluids. In the pituitary it co-localises with many peptide and non-peptide mediators such as corticotropin-like intermediate peptide (CLIP), adrenocorticotrophic hormone (ACTH), melanocyte-stimulating hormone (MSH), thyroid-stimulating hormone (TSH) and melanin concentrating hormone (MCH). Delta-sleep-inducing peptide is abundant in the gut secretory cells and in the pancreas where it co-localises with glucagon. | [Uses]
Delta-sleep-inducing peptide (DSIP) was isolated, characterized, and synthesized more than 6 years ago. It can help relieve stress and aches that keep you from restful sleep. It was first proposed as a sleep-peptide and this remains the prevalent impression of its function. DSIP is a natural sleep-promoting nonapeptide with a few beneficial functions. The peptide has been used to treat poor sleep, pain conditions, stress-related symptoms, and more. Delta-Sleep Inducing Peptide trifluoroacetate salt H-Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu-OH trifluoroacetate salt is a useful research chemical compound. | [Definition]
A nonapeptide that is found in neurons, peripheral organs, and plasma. This neuropeptide induces mainly delta sleep in mammals. In addition to sleep, the peptide has been observed to affect electrophysiological activity, neurotransmitter levels in the brain, circadian and locomotor patterns, hormonal levels, psychological performance, and the activity of neuropharmacological drugs including their withdrawal. | [benefits]
Can restore disturbed sleep patterns;Can promote LH and GH release;Can reduce persistent/chronic pain;Can modulate cortisol production. | [References]
[1] E. Koplik. “Delta sleep-inducing peptide and Deltaran: Potential approaches to antistress protection.” Neuroscience and Behavioral Physiology 38 1 (2008): 953–957.
| [Physiological effects]
Delta sleep-inducing peptide (DSIP) has several physiological effects in addition to its ability to promote sleep in animals. It is also involved in neuroendocrine regulation and release of anterior pituitary hormones. In rodents and humans, Delta sleep-inducing peptide (DSIP) influence in the secretion of adrenocorticotropic hormone (ACTH), luteinizing hormone (LH) and growth hormone (GH). It also plays a role in the regulation of the circadian rhythms and and can help restore disturbed patterns of sleep. | [Dosage]
DSIP is currently being studied for the treatment of conditions such as narcolepsy, hypertension, and insomnia. It is recommended to inject 0.1 ml of DSIP subcutaneously every day before bedtime for effective results. |
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