| Identification | More | [Name]
N-Acetyl-L-glutamic acid | [CAS]
1188-37-0 | [Synonyms]
ACETYL-L-GLUTAMIC ACID
AC-GLU-OH
L-2-ACETAMIDOGLUTARIC ACID
N-ACETYL-L-GLU
N-ACETYL-L-GLUTAMIC ACID
N-AC-L-GLU
N-ALPHA-ACETYL-L-GLUTAMIC ACID
acetylglutamicacid
L-Glutamic acid, N-acetyl-
l-glutamicaci
l-n-acetylglutamicacid
n-acetylglutamate
n-acetylglutamic
N-Acetylglutamic acid
n-acetyl-glutamicaci
n-acetylglutamicacid
n-acetyl-l-glutamicaci
N-Acetyl-L-glutamate
N-Acetyl-L-Glutamic
N-Acetyl-L(DL)-Glutamic acid | [EINECS(EC#)]
214-708-4 | [Molecular Formula]
C7H11NO5 | [MDL Number]
MFCD00002802 | [Molecular Weight]
189.17 | [MOL File]
1188-37-0.mol |
| Chemical Properties | Back Directory | [Appearance]
white crystalline powder | [Melting point ]
194-196 °C(lit.) | [alpha ]
-16 º (c=1, water) | [Boiling point ]
324.41°C (rough estimate) | [density ]
1.4119 (rough estimate) | [FEMA ]
4752 | N-ACETYL GLUTAMATE | [refractive index ]
-15 ° (C=1, H2O) | [storage temp. ]
0-6°C | [solubility ]
36g/l (Lit.) | [form ]
Solid | [pka]
3.45±0.10(Predicted) | [color ]
White | [Optical Rotation]
[α]22/D 15.6°, c = 1 in H2O | [Water Solubility ]
2.7 g/100 mL (20 ºC) | [JECFA Number]
2269 | [BRN ]
1727473 | [Major Application]
peptide synthesis | [Cosmetics Ingredients Functions]
SKIN CONDITIONING | [Cosmetic Ingredient Review (CIR)]
N-Acetyl-L-glutamic acid (1188-37-0) | [InChI]
1S/C7H11NO5/c1-4(9)8-5(7(12)13)2-3-6(10)11/h5H,2-3H2,1H3,(H,8,9)(H,10,11)(H,12,13)/t5-/m0/s1 | [InChIKey]
RFMMMVDNIPUKGG-YFKPBYRVSA-N | [SMILES]
CC(=O)N[C@@H](CCC(O)=O)C(O)=O | [LogP]
-2.131 (est) | [CAS DataBase Reference]
1188-37-0(CAS DataBase Reference) | [NIST Chemistry Reference]
N-acetyl-l-glutamic acid(1188-37-0) | [EPA Substance Registry System]
1188-37-0(EPA Substance) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H302-H315-H319-H335 | [Precautionary statements ]
P271-P261-P280 | [Safety Statements ]
S24/25:Avoid contact with skin and eyes . | [WGK Germany ]
2
| [RTECS ]
LZ9725000
| [TSCA ]
Yes | [REACH Registrations]
Active | [HS Code ]
29241900 | [Storage Class]
11 - Combustible Solids |
| Hazard Information | Back Directory | [Chemical Properties]
white crystalline powder | [Uses]
N-Acetyl-L-glutamic Acid is the N-Acetyl analogue of the non-essential amino acid, L-glutamic acid (G596960). N-Acetyl-L-glutamic Acid activates carbamoyl phosphate synthetase in the urea cycle. | [Uses]
N-Acetyl-L-glutamic acid is used as pharmaceutical intermediates. | [Uses]
Substrate for acetylglutamate kinase. Inhibitor of N-acetyl-L-glutamate synthetase | [Definition]
ChEBI: N-acetyl-L-glutamic acid is an N-acyl-L-amino acid that is L-glutamic acid in which one of the amine hydrogens is substituted by an acetyl group. It has a role as a Saccharomyces cerevisiae metabolite and a human metabolite. It is a N-acetyl-L-amino acid and a N-acyl-L-glutamic acid. It is functionally related to a L-glutamic acid. It is a conjugate acid of a N-acetyl-L-glutamate(1-). | [reaction suitability]
reaction type: solution phase peptide synthesis | [Purification Methods]
A likely impurity is glutamic acid. Crystallise it from boiling water. It inhibits N-acetyl-L-glutamate synthase. [Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 p 1948 1961, Shigesada & Tatibana Eur J Biochem 84 285 1978, Coude Biochem Biophys Res Commun 102 1016 1981, Beilstein 4 IV 3047.] |
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