| Identification | Back Directory | [Name]
Benzenesulfonamide,4-[(3-chloro-1,4-dihydro-1,4-dioxo-2-naphthalenyl)amino]-N-2-pyridinyl- | [CAS]
6298-15-3 | [Synonyms]
BC-23
NSC 45382)
BC-23
(BC23
Benzenesulfonamide,4-[(3-chloro-1,4-dihydro-1,4-dioxo-2-naphthalenyl)amino]-N-2-pyridinyl- | [Molecular Formula]
C21H14ClN3O4S | [MDL Number]
MFCD32671966 | [MOL File]
6298-15-3.mol | [Molecular Weight]
439.87 |
| Chemical Properties | Back Directory | [Melting point ]
262 °C (decomp)(Solv: water (7732-18-5); 1,4-dioxane (123-91-1)) | [Boiling point ]
615.9±65.0 °C(Predicted) | [density ]
1.56±0.1 g/cm3(Predicted) | [storage temp. ]
+2C to +8C | [solubility ]
DMSO: 25mg/mL | [form ]
Dark red solid | [pka]
8.47±0.10(Predicted) | [color ]
Orange to red |
| Hazard Information | Back Directory | [Uses]
BC-23 (NSC 45382) is a proteasome inhibitor. BC-23 exhibits good inhibition of CT-L activity of the proteasome and is selective for malignant over normal cells[1][2]. | [References]
[1] Lawrence HR, et, al. Synthesis and biological evaluation of naphthoquinone analogs as a novel class of proteasome inhibitors. Bioorg Med Chem. 2010 Aug 1;18(15):5576-92. DOI:10.1016/j.bmc.2010.06.038
[2] Zhang Q, et, al. Enhancement of Radiation Sensitivity in Lung Cancer Cells by a Novel Small Molecule Inhibitor That Targets the β-Catenin/Tcf4 Interaction. PLoS One. 2016 Mar 25;11(3):e0152407. DOI:10.1371/journal.pone.0152407 |
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| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
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