| Identification | Back Directory | [Name]
2-(3-CHLOROPHENYL)MALONDIALDEHYDE | [CAS]
6299-85-0 | [Synonyms]
6-c
NSC45044
2-(3-CHLOROPHENYL)MALONDIALDEHYDE
2,6-dichloropyrimidine-4-carboxylate
2,4-dichloropyrimidine-6-carboxylate
2,4-Dichloro-6-(methoxycarbonyl)pyrimidine
Methyl 2,6-dichloropyrimidine-4-carboxylate
Methyl 2,4-dichloropyrimidine-6-carboxylate
Methyl2,4-dichloropyrimidine-6-carboxylate99%
Tert-butyl n-(2-(4-nitrophenyl)ethyl)carbamate
Methyl 2,4-dichloropyrimidine-6-carboxylate 99%
2,6-DICHLORO-PYRIMIDINE-4-CARBOXYLIC ACID ETHYL ESTER
2,6-Dichloro-pyrimidine-4-carboxylic acid methyl ester
4-PyriMidinecarboxylicacid, 2,6-dichloro-, Methyl ester
4-Methyl-2-(3,4-dichlorophenyl)thiazole-5-carboxylicacid | [EINECS(EC#)]
674-238-4 | [Molecular Formula]
C6H4Cl2N2O2 | [MDL Number]
MFCD02261887 | [MOL File]
6299-85-0.mol | [Molecular Weight]
207.02 |
| Chemical Properties | Back Directory | [Melting point ]
54-56 | [Boiling point ]
306 ºC | [density ]
1.503 | [Fp ]
139 ºC | [storage temp. ]
Inert atmosphere,2-8°C | [form ]
White to off white to faint cream flakes | [pka]
-5.83±0.30(Predicted) | [Appearance]
Off-white to yellow Solid | [InChI]
InChI=1S/C6H4Cl2N2O2/c1-12-5(11)3-2-4(7)10-6(8)9-3/h2H,1H3 | [InChIKey]
DQNQNLWKAGZNIT-UHFFFAOYSA-N | [SMILES]
C1(Cl)=NC(Cl)=CC(C(OC)=O)=N1 |
| Hazard Information | Back Directory | [Synthesis]
To a stirred suspension of orotic acid (20.00 g, 128.140 mmol) in POCI3(75 ml) was added DMF (catalytic amount, -0.5 ml) at ambient temperature, and the resulting reaction mixture was refluxed for 3 h. Excess of POC was removed by vacuum distillation after 3h of reflux. The obtained slurry was poured slowly into a 5 per cent mixture of methanol in chloroform (200 ml) at 0°C and stirred for 30 min. The organic layer obtained was washed with a saturated solution of NaHCC>3 (3 x 200 ml). The combined organic phase was dried over Na2S04, filtered and concentrated under reduced pressure, yielding Methyl 2,4-dichloropyrimidine-6-carboxylate (19.00 g, 91 .800 mmol). | [References]
[1] Patent: WO2018/167276, 2018, A1. Location in patent: Paragraph 00131; 00132; 00133 |
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