| | Identification | More |  | [Name] 
 2,4-Dichlorophenylacetonitrile
 |  | [CAS] 
 6306-60-1
 |  | [Synonyms] 
 2,4-DCCN
 2,4-DICHLOROBENZYL CYANIDE
 2,4-DICHLOROPHENYLACETONITRILE
 2-(2,4-Dichlorophenyl)acetonitrile
 2,4-Dichlorobenzeneacetonitrile
 Acetonitrile, (2,4-dichlorophenyl)-
 2,4-dichloro cyanobenzene
 2,4-Dichlorophenylacetonitrile,98%
 (2,4-Dichlorphenyl)acetonitril
 2,4-DICHLOROPHENYLACETONITRILE/2,4-DICHLOROBENZYL CYANIDE
 11) 2,4-DI CHLORO BENZYL CYANIDE
 Benzeneacetonitrile, 2,4-dichloro-
 2,4-DICHLOROPHENYLACETONITRILE, 99+%
 |  | [EINECS(EC#)] 
 228-621-4
 |  | [Molecular Formula] 
 C8H5Cl2N
 |  | [MDL Number] 
 MFCD00001899
 |  | [Molecular Weight] 
 186.04
 |  | [MOL File] 
 6306-60-1.mol
 | 
 | Safety Data | Back Directory |  | [Hazard Codes ] 
 Xi,Xn
 |  | [Risk Statements ] 
 R36/37/38:Irritating to eyes, respiratory system and skin .
 R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
 |  | [Safety Statements ] 
 S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
 S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
 |  | [RIDADR ] 
 3276
 |  | [WGK Germany ] 
 1
 
 |  | [HazardClass ] 
 6.1
 |  | [PackingGroup ] 
 III
 |  | [HS Code ] 
 29269090
 | 
 | Hazard Information | Back Directory |  | [Chemical Properties] 
 white to light yellow crystal powder
 |  | [Uses] 
 
 2,4-Dichlorophenylacetonitrile was used in the synthesis of 2,4-dichloromandelic acid. |  | [Synthesis] 
 
 General method: 2,4-dichlorobenzyl chloride (1.0 mmol) was mixed with sodium cyanide (2 mmol) in deionized water (5 mL) and polyethylene glycol modified diisocyanate (PEG-MDIL, 0.2 g) was added. The reaction suspension was placed under reflux conditions and the reaction mixture was stirred using a magnetic stirrer for the reaction time referred to in Table 2.After completion of the reaction, the mixture was extracted with ether (2 × 10 mL). The organic extracts were combined, dried with anhydrous calcium chloride and subsequently concentrated under reduced pressure. By this method, the target product 2,4-dichlorophenylacetonitrile was obtained in good to excellent isolated yields (see Scheme 3). |  | [References] 
 [1] Organic Preparations and Procedures International,  2011,  vol. 43,  # 3,  p. 285 - 291
 [2] Journal of Molecular Liquids,  2015,  vol. 202,  p. 34 - 39
 [3] Journal of Molecular Catalysis A: Chemical,  2012,  vol. 365,  p. 80 - 86
 [4] Applied Organometallic Chemistry,  2018,  vol. 32,  # 2,
 [5] Catalysis Communications,  2012,  vol. 18,  p. 102 - 105
 | 
 |  |