| Identification | More | [Name]
2,6-Dimethylbenzoic acid | [CAS]
632-46-2 | [Synonyms]
2,6-DIMETHYLBENZOIC ACID
M-XYLENE-2-CARBOXYLIC ACID
RARECHEM AL BO 0401
TIMTEC-BB SBB007881
VIC-M-XYLYLIC ACID
2,6-dimethyl-benzoicaci
Benzoic acid, 2,6-dimethyl-(7CI,8CI,9CI)
Benzoic acid, 2,6-dimethyl-
2,6-Dimethylbenzoic acid, 98+% | [EINECS(EC#)]
211-177-0 | [Molecular Formula]
C9H10O2 | [MDL Number]
MFCD00002483 | [Molecular Weight]
150.17 | [MOL File]
632-46-2.mol |
| Chemical Properties | Back Directory | [Appearance]
white to pale cream crystalline powder | [Melting point ]
114-116 °C (lit.) | [Boiling point ]
160 °C / 17mmHg | [density ]
1.0937 (estimate) | [refractive index ]
1.5236 (estimate) | [storage temp. ]
Sealed in dry,Room Temperature | [form ]
Crystalline Powder | [pka]
pKa: 3.362(25°C) | [color ]
White to pale cream | [Detection Methods]
HPLC | [BRN ]
1863791 | [InChI]
InChI=1S/C9H10O2/c1-6-4-3-5-7(2)8(6)9(10)11/h3-5H,1-2H3,(H,10,11) | [InChIKey]
HCBHQDKBSKYGCK-UHFFFAOYSA-N | [SMILES]
C(O)(=O)C1=C(C)C=CC=C1C | [LogP]
2.210 | [CAS DataBase Reference]
632-46-2(CAS DataBase Reference) | [NIST Chemistry Reference]
Benzoic acid, 2,6-dimethyl-(632-46-2) |
| Questions And Answer | Back Directory | [Synthesis]
At room temperature, 2,6-dimethylphenylboronic acid (150 mg), KOMe (2.0 equivalent), and catalyst [(IPr)CuCl] (14.4 mg, 3.0 mol%) were stirred for 5-10 minutes under a nitrogen atmosphere. The reaction tube was filled with carbon dioxide by applying vacuum and CO2 purging for 4-5 cycles. The reaction tube was sealed, and the reaction was stirred at 70°C for 24 hours. The reaction mixture was then carefully quenched by adding 2.0 M hydrochloric acid aqueous solution. The reaction mixture was diluted with water, extracted three times with ethyl acetate, and the combined organic phases were washed with brine. The organic phases were dried on anhydrous sodium sulfate, filtered, and the solvent was removed under reduced pressure. The product was then separated and purified by silica gel column chromatography to obtain the target product molecule, 2,6-dimethylbenzoic acid.
 Figure 2,6-Dimethylbenzoic Acid Synthetic Route |
| Hazard Information | Back Directory | [Chemical Properties]
white to pale cream crystalline powder | [Uses]
2,6-Dimethylbenzoic acid is a benzoic acid derivative used in the preparation of antiinflammatory and antirheumatic agents. And it is also a potential geothermal tracer.
| [Definition]
ChEBI: A dimethylbenzoic acid in which the two methyl groups are located at positions 2 and 6. | [Synthesis Reference(s)]
Tetrahedron, 36, p. 2409, 1980 DOI: 10.1016/0040-4020(80)80219-5 | [General Description]
Crystal structure of 2,6-dimethylbenzoic acid was studied by three-dimensional X-ray methods. | [Purification Methods]
Steam distil the acid, and crystallise it from EtOH or H2O (m 116.3-116.7o). The N-dimethylamide has m 62-63o (from Et2O). [Beilstein 9 H 531, 9 IV 1798.] |
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