| Identification | More | [Name]
DIETHYL 1,4-DIHYDRO-2,4,6-TRIMETHYL-3,5-PYRIDINEDICARBOXYLATE | [CAS]
632-93-9 | [Synonyms]
1,4-DIHYDRO-2,4,6-TRIMETHYL-3,5-PYRIDINEDICARBOXYLIC ACID DIETHYL ESTER
3,5-DICARBETHOXY-1,4-DIHYDRO-2,4,6-TRIMETHYLPYRIDINE
3,5-DIETHOXYCARBONYL-1,4-DIHYDRO-2,4,6-COLLIDINE
DIETHYL 1,4-DIHYDRO-2,4,6-TRIMETHYL-3,5-PYRIDINEDICARBOXYLATE
DIETHYL 1,4-DIHYDRO-2,4,6-TRIMETHYLPYRIDINE-3,5-DICARBOXYLATE
5-pyridinedicarboxylicacid,1,4-dihydro-2,4,6-trimethyl-diethylester
Dicarbethoxydihydrocollidine
diethyl dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylate
3,5-dicarbethoxy-1,4-dihydrocollidine, DDC
1,4-Dihydro-2,4,6-collidine-3,5-dicarboxylic acid diethyl ester
1,4-Dihydro-2,4,6-trimethylpyridine-3,5-dicarboxylic acid diethyl ester
1,4-Dihydro-3,5-dicarbethoxycollidine
3,5-Bis(ethoxycarbonyl)-1,4-dihydrocollidine
Diethyl 1,4-dihydro-s-collidine-3,5-dicarboxylate | [EINECS(EC#)]
211-188-0 | [Molecular Formula]
C14H21NO4 | [MDL Number]
MFCD00005950 | [Molecular Weight]
267.32 | [MOL File]
632-93-9.mol |
| Chemical Properties | Back Directory | [Appearance]
almost white crystalline powder | [Melting point ]
130-132 °C(lit.) | [Boiling point ]
410.51°C (rough estimate) | [density ]
1.1116 (rough estimate) | [refractive index ]
1.5280 (estimate) | [storage temp. ]
Flammables area | [solubility ]
DMF: 30 mg/ml; DMF:PBS (pH 7.2); (1:7): 0.125 mg/ml; DMSO: 20 mg/ml; Ethanol: 20 mg/ml | [form ]
powder to crystal | [pka]
3.53±0.70(Predicted) | [color ]
White to Orange to Green | [InChI]
InChI=1S/C14H21NO4/c1-6-18-13(16)11-8(3)12(14(17)19-7-2)10(5)15-9(11)4/h8,15H,6-7H2,1-5H3 | [InChIKey]
CDVAIHNNWWJFJW-UHFFFAOYSA-N | [SMILES]
C1(C)NC(C)=C(C(OCC)=O)C(C)C=1C(OCC)=O | [CAS DataBase Reference]
632-93-9(CAS DataBase Reference) | [EPA Substance Registry System]
3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,4,6-trimethyl-, diethyl ester (632-93-9) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S37/39:Wear suitable gloves and eye/face protection . | [WGK Germany ]
3
| [RTECS ]
US7979375 | [TSCA ]
TSCA listed | [HS Code ]
2933.39.9200 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Description]
Diethyl 1,4-dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylate (DDC) inhibits heme production by inhibiting ferrochelatase, the enzyme that catalyzes the addition of Fe2+ to protoporphyrin IX to create heme B.1 Chronic DDC administration induces Mallory-Denk body formation, a feature of alcoholic and non-alcoholic hepatitis, and reduces IL-12A methylation in mouse liver.2,3 | [Chemical Properties]
almost white crystalline powder | [Uses]
Diethyl 1,4-dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylate was used to induce Mallory-Denk body formation in mice in vivo. | [Definition]
ChEBI: A dihydropyridine that is 2,4,6-trimethyl-1,4-dihydropyridine substituted by ethoxycarbonyl groups at positions 3 and 5. | [Biochem/physiol Actions]
Diethyl 1,4-dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylate blocks the heme synthesis and prevents the induction of hepatic heme oxygenase-1 in mice. | [Purification Methods]
Crystallise the ester from hot EtOH/water mixture. [Beilstein 22 H 147, 22 I 529, 22 II 100, 22 III/IV 1594.] | [References]
[1] J. ONISAWA R L. Effects of diethyl-1, 4-dihydro-2, 4,6-trimethylpyridine-3,5-dicarboxylate on the metabolism of porphyrins and iron.[J]. The Journal of Biological Chemistry, 1963, 44 1: 724-727. DOI: 10.1016/s0021-9258(18)81326-6
[2] QX YUAN. Mallory body induction in drug-primed mouse liver[J]. Hepatology, 1996, 24 3: Pages 603-612. DOI: 10.1053/jhep.1996.v24.pm0008781332
[3] J. OLIVA S. W F. Changes in IL12A methylation pattern in livers from mice fed DDC[J]. Experimental and molecular pathology, 2012, 92 2: Pages 191-193. DOI: 10.1016/j.yexmp.2012.01.001 |
| Spectrum Detail | Back Directory | [Spectrum Detail]
DIETHYL 1,4-DIHYDRO-2,4,6-TRIMETHYL-3,5-PYRIDINEDICARBOXYLATE(632-93-9)MS
DIETHYL 1,4-DIHYDRO-2,4,6-TRIMETHYL-3,5-PYRIDINEDICARBOXYLATE(632-93-9)1HNMR
DIETHYL 1,4-DIHYDRO-2,4,6-TRIMETHYL-3,5-PYRIDINEDICARBOXYLATE(632-93-9)IR1
DIETHYL 1,4-DIHYDRO-2,4,6-TRIMETHYL-3,5-PYRIDINEDICARBOXYLATE(632-93-9)IR2
DIETHYL 1,4-DIHYDRO-2,4,6-TRIMETHYL-3,5-PYRIDINEDICARBOXYLATE(632-93-9)Raman
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| Well-known Reagent Company Product Information | Back Directory | [Acros Organics]
Diethyl 1,4-dihydro-2,4,6-trimethyl-3,5-pyridinedicarboxylate, 99%(632-93-9) | [Sigma Aldrich]
632-93-9(sigmaaldrich) | [TCI AMERICA]
3,5-Diethoxycarbonyl-1,4-dihydro-2,4,6-collidine,>98.0%(GC)(632-93-9) |
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| Company Name: |
Energy Chemical
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| Tel: |
021-021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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