| Identification | More | [Name]
2-Methoxy-5-nitrophenol | [CAS]
636-93-1 | [Synonyms]
2-METHOXY-5-NITROPHENOL
3-HYDROXY-4-METHOXYNITROBENZENE
5-NITROGUAIACOL
NITROGUAIACOL(5-)
2-Hydroxy-1-methoxy-4-nitrobenzene
3-Hydroxy-4-methoxynitrobenzene~5-Nitroguaiacol
5-Nitroguaiacol (3-Hydroxy-4-methoxynitrobenzene)
2-Hydroxy-4-nitroanisole
5 nitroguaiacol, 2-methoxy-5-nitrophenol
Phenol, 2-methoxy-5-nitro-
2-Methoxy-5-nitrophenol 98%
2-METHOXY-5-NITROPHENOL/5-NITROGUAIACOL
2-METHOXY-5-NITROANILINE | [EINECS(EC#)]
211-269-0 | [Molecular Formula]
C7H7NO4 | [MDL Number]
MFCD00015561 | [Molecular Weight]
169.13 | [MOL File]
636-93-1.mol |
| Questions And Answer | Back Directory | [Synthesis]
Phenol (0.10 mol) was dissolved in water containing 40% sodium hydroxide (10 mL, 0.1 mol) and heated to allow it to dissolve slowly. The water was then concentrated by evaporation under reduced pressure. PEG 400 (1.6 g, approximately 0.04 mol) and the alkylating agent dimethyl sulfate (0.11 mol) were slowly added to the reaction system with vigorous stirring. The reaction was accelerated by heating and monitored by HPLC and TLC until the phenol was completely converted. The mixture was then poured into a hot aqueous solution of sodium hydroxide (5%) or water (80-90°C, 100 mL) and stirred to allow the product to precipitate or separate into layers. The precipitate or organic layer was washed with water (three times, 50 mL each time). HPLC showed that the purity of the product obtained via this route was above 96%. For higher purity, recrystallization with a suitable solvent or distillation under vacuum can be performed. Caution: Dimethyl sulfate is a highly toxic compound; extreme caution must be exercised during handling. It must never come into contact with skin or gloves. 
|
| Chemical Properties | Back Directory | [Melting point ]
103-107 °C (lit.) | [Boiling point ]
110-112 °C/1 mmHg (lit.) | [density ]
1.3375 (estimate) | [refractive index ]
1.5830 (rough estimate) | [Fp ]
110-112°C/1mm | [storage temp. ]
Inert atmosphere,Room Temperature | [solubility ]
Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
8.31±0.19(Predicted) | [color ]
Light Yellow to Light Brown | [Detection Methods]
HPLC | [BRN ]
2047074 | [InChI]
InChI=1S/C7H7NO4/c1-12-7-3-2-5(8(10)11)4-6(7)9/h2-4,9H,1H3 | [InChIKey]
KXKCTSZYNCDFFG-UHFFFAOYSA-N | [SMILES]
C1(O)=CC([N+]([O-])=O)=CC=C1OC | [CAS DataBase Reference]
636-93-1(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn,Xi | [Risk Statements ]
R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [RIDADR ]
2811 | [WGK Germany ]
3
| [Hazard Note ]
Irritant | [PackingGroup ]
III | [HS Code ]
29095090 |
| Hazard Information | Back Directory | [Chemical Properties]
Yellow to light brown powder | [Uses]
2-Methoxy-5-nitrophenol is used in the synthesis of potent VEGF and tyrosine kinase inhibitors. Also used in the synthesis of GABA analogues and phosphodiesterase inhibitors such as rolipram. | [Definition]
ChEBI: 2-Methoxy-5-nitrophenol is a member of 3-nitrophenols. | [Synthesis Reference(s)]
Chemical and Pharmaceutical Bulletin, 28, p. 1287, 1980 DOI: 10.1248/cpb.28.1287 | [General Description]
2-Methoxy-5-nitrophenol is the substitution photoproduct formed on irradiation of 2-chloro-4-nitroanisole at 25°C in aqueous NaOH. |
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| Company Name: |
Henan Jiuke Chemical Co. LTD Gold
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| Telephone: |
0370-2071226 17303700913 |
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www.chemicalbook.com/ShowSupplierProductsList1506642/0_EN.htm |
| Company Name: |
J & K SCIENTIFIC LTD.
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18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Alfa Aesar
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400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
| Company Name: |
Energy Chemical
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| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
| Company Name: |
Jia Xing Isenchem Co.,Ltd
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| Telephone: |
0573-85285100 18627885956 |
| Website: |
https://www.chemicalbook.com/ShowSupplierProductsList14265/0_EN.htm |
| Company Name: |
China Langchem Inc.
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| Telephone: |
021-58956006,021-58950017 15800617331 |
| Website: |
www.isotopemall.com/ |
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