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638-94-8

638-94-8 Structure

638-94-8 Structure
IdentificationMore
[Name]

Desonide
[CAS]

638-94-8
[Synonyms]

(11b,16a)-11,21-dihydroxy-16,17-((1-methylethylidene)bis(oxy))-pregna-1,4-diene-3,20-dione
1,4-PREGNADIEN-11-BETA, 16-ALPHA, 17,21-TETROL-3,20-DIONE 16,17-ACETONIDE
DESONIDE
PREDNACINOLONE
16-alpha-hydroxyprednisole-16,17-acetonide
17-acetonide,16-alpha-hydroxy-prednisolone-1
d-2083
steroderm
Desonidemicro
(11,16a)-11,21-Dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione
16a-Hydroxyprednisolone Acetonide
Locapred
Topifug
Tridesilon
16a-Hydroxyprednisole-16,17-acetonide
Pregna-1,4-diene-3,20-dione, 11,21-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]-, (11b,16a)-
[EINECS(EC#)]

211-351-6
[Molecular Formula]

C24H32O6
[MDL Number]

MFCD00866151
[Molecular Weight]

416.51
[MOL File]

638-94-8.mol
Chemical PropertiesBack Directory
[Melting point ]

272-274?C
[Boiling point ]

580.1±50.0 °C(Predicted)
[density ]

1.30±0.1 g/cm3(Predicted)
[storage temp. ]

Sealed in dry,2-8°C
[solubility ]

DMF (Slightly, Sonicated), DMSO (Sparingly), Methanol (Slightly, Heated)
[form ]

Solid
[pka]

12.87±0.10(Predicted)
[color ]

White to Off-White
[Usage]

Anti-inflammatory
[CAS DataBase Reference]

638-94-8(CAS DataBase Reference)
Material Safety Data Sheet(MSDS)Back Directory
[msds information]

Desonide(638-94-8).msds
Safety DataBack Directory
[HS Code ]

2937290000
[Toxicity]

LD50 in rats (mg/kg): 93 s.c. (Phillips)
Hazard InformationBack Directory
[Chemical Properties]

Off-White Solid
[Originator]

Tridesilon,Dome,US,1972
[Uses]

antifungal
[Uses]

Anti-inflammatory. Desonide has also been found as an impurity in budesonide (B689490).
[Definition]

ChEBI: Triamcinolone acetonide with hydrogen instead of the fluorine substituent at position 9. A corticosteroid anti-inflammatory, it is used topically as a cream, ointment or lotion for the treatment of various skin disorders.
[Indications]

Desonide (DesOwen, Tridesilon) is a synthetic corticosteroid.
[Manufacturing Process]

Preparation of 11β,21-Dihydroxy-16α,17α-Isopropylidenedioxy-1,4- Pregnadiene-3,20-Dione: A solution of 11β,16α,17α,21-tetrahydroxy-1,4- pregnadiene-3,20-dione (40 mg) in acetone (10 ml) containing hydrochloric acid (three drops; d 1.19) is boiled 3n the steam bath for two minutes and then allowed to stand for eighteen hours at room temperature. The reaction mixture is diluted with water (50 ml) and extracted with chloroform (3x25 ml), the combined extracts then being washed with water (30 ml) and dried over anhydrous sodium sulfate. The residue obtained by removal of solvent crystallized from ethyl acetate-petroleum ether as small plates (25 mg), melting point 257°-260°C.
[Brand name]

Desowen (Galderma); Tridesilon (Perrigo).
[Therapeutic Function]

Antiinflammatory
Spectrum DetailBack Directory
[Spectrum Detail]

Desonide(638-94-8)1HNMR
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