| Identification | Back Directory | [Name]
Etimizol | [CAS]
64-99-3 | [Synonyms]
Etimizol
Antiffine
Ethymisol
Ethymizol
Etimizole
Ethymisole
Ethimizole
Etimizol, 99.5%
Ethylnorantifein
Ethylnorantifeine
Ethylnorantiffeine
Etimizol(Ethymisole
N,N'-Dimethyl-1-ethylimidazole-4,5-dicarboxamide
ETIMIZOL(ETHYMISOLE; ANTIFFINE; ETHYLNORANTIFEIN)
1H-Imidazole-4,5-dicarboxamide, 1-ethyl-N4,N5-dimethyl-
1-Ethyl-4-N,5-N-dimethyl-1H-imidazole-4,5-dicarboxamide
ETHYMISOLE; ANTIFFINE; ETHIMIZOLE; ETHYLNORANTIFEIN; ETHYLNORANTIFEINE; ETHYLNORANTIFFEINE; ETHYMISOL; ETHYMISOLE; ETIMIZOLE | [Molecular Formula]
C9H14N4O2 | [MDL Number]
MFCD00458382 | [MOL File]
64-99-3.mol | [Molecular Weight]
210.23 |
| Chemical Properties | Back Directory | [Melting point ]
143-144℃ | [Boiling point ]
563.4±35.0 °C(Predicted) | [density ]
1.26±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Ethanol: ≥ 33.33 mg/mL (158.54 mM) | [form ]
Solid | [pka]
14.22±0.46(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Etimizol(Ethymisole; Antiffine; Ethylnorantifein) was shown to relieve amnesia effectively in the origin of which there is the hypoxic component (hypobaric hypoxia, actinomycin D, mechanical injury of the brain). Etimizol can decrease the K-+ permeability of neurons' membrane during action potential. | [in vivo]
The time interval between administration ofetimizol (3 mg/kg) and the onset of learning varied between 0.5 and 3 h in the several series. Etimizol (Ethymisole) did not facilitate the learning in rats whatever the time of administration and biological modality of reinforcement [1]. After administration of Etimizol (Ethymisole) at doses of 10 or 1 mg/loop mean residence time of etimizol in the loop was 20.1 and 7.6 min, respectively, with mean standard deviation being 3.1 and 0.8, respectively [2]. Extracellular application of 5--10 mM/L Etimizol (Ethymisole) exerted a specific effect on the giant neurons of the Coretus corneus isolated nervous system: action potential duration increased significantly, speed of development of its descending phase decreased, as well as the trace hyperpolarization amplitude [3]. | [References]
[1] Borisova GIu. Effect of etimizol on instrumental learning in rats. Biull Eksp Biol Med. 1985 Jun;99(6):705-6. PMID:4016262
[2] Trnovec T, et al. Etimizol absorption from the small intestine in dogs: the dependence on dosage. Biull Eksp Biol Med. 1986 Dec;102(12):729-30. PMID:3801627
[3] Vislobokov AI, et al. Elektrophysiological parameters of mollusk neurons under the influence of etimizol. Fiziol Zh SSSR Im I M Sechenova. 1975 Jun;61(6):917-24. PMID:1132537 |
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