| Identification | Back Directory | [Name]
DIETHYL-1,3,6,8-TETRAHYDRO-1,3,6,8-TETRAOXOBENZO[IMN][3,8]PHENANTHROLINE-2,7-DIACETATE | [CAS]
64005-90-9 | [Synonyms]
PIB
PiB >=98% (HPLC)
WNKQGFNIIHNGQM-UHFFFAOYSA-N
PPIase-Parvulin Inhibitor - CAS 64005-90-9 - Calbiochem
DIETHYL-1,3,6,8-TETRAHYDRO-1,3,6,8-TETRAOXOBENZO[IMN][3,8]PHENANTHROLINE-2,7-DIACETATE
Benzo[lmn][3,8]phenanthroline-2,7-diacetic acid, 1,3,6,8-tetrahydro-1,3,6,8-tetraoxo-, 2,7-diethyl ester | [Molecular Formula]
C22H18N2O8 | [MDL Number]
MFCD00333607 | [MOL File]
64005-90-9.mol | [Molecular Weight]
438.39 |
| Chemical Properties | Back Directory | [storage temp. ]
2-8°C | [solubility ]
DMSO: soluble1-2mg/mL (warmed) | [form ]
Brownish solid | [color ]
white to light brown | [InChI]
InChI=1S/C18H18N2O8/c1-3-23-15(21)9-19-25-11-5-7-13-18-14(8-6-12(26-19)17(11)18)28-20(27-13)10-16(22)24-4-2/h5-8H,3-4,9-10H2,1-2H3 | [InChIKey]
RUZSTTGSEVILES-UHFFFAOYSA-N | [SMILES]
C12=CC=C3C4C1=C(C=CC=4ON(CC(OCC)=O)O3)ON(CC(OCC)=O)O2 |
| Hazard Information | Back Directory | [Uses]
PPIase-Parvulin inhibitor (compound B) is a cell-permeable inhibitor targeting PPIase Pin1 and Par14, with IC50s of 1.5 and 1.0 μM, respectively. PPIase-Parvulin inhibitor has anticancer activity and inhibits the growth and proliferation of mouse embryonic fibroblasts (MEFs)[1]. | [Biological Activity]
PiB is an inhibitor of the peptidylprolyl isomerase Pin-1. Inhibition of Pin-1 leads to destabilization of the transcription factor Nanogwhich is required for maintenance of embryonic stem cell cultures. | [References]
[1] Uchida T, et al. Pin1 and Par14 peptidyl prolyl isomerase inhibitors block cell proliferation. Chem Biol. 2003 Jan;10(1):15-24. DOI:10.1016/s1074-5521(02)00310-1 |
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| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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