| Identification | Back Directory | [Name]
Spectinomycin sulfate tetrahydrate | [CAS]
64058-48-6 | [Synonyms]
U-18409E
CTK8G3179
SPECTINOMYCINHCL
Trobicin sulfate
U 18409E, ANTIBIOTIC
Sulfate tetrahydrate
SPECTINOMYCIN SULFATE
SPECTINOMYCIN SULPHATE
Spectinomycin sulfate tetrahydrate
Spectinnomysin sulfate tetrahydrate
Spectinomycin, tetrahydrate, sulfate
Actinospectacin, tetrahydrate, sulfate
Spectinomycin sulfate tetrahydrate CRS
SpectinoMycin sulfate tetrahydrate CGMP/FDA
TIANFUCHEM--64058-48-6---Spectinomycin sulfate tetrahydrate
(2R,4AR,5aR,6S,7S,8R,9S,9aR,10aS)-4a,7,9-trihydroxy-2-methyl-6,8-bis(methylamino)octahydro-2H-benzo[b]pyrano[2,3-e][1,4]dioxin-4(3H)-one sulfate tetrahydrate | [EINECS(EC#)]
613-422-0 | [Molecular Formula]
C14H26N2O11S | [MDL Number]
MFCD29915599 | [MOL File]
64058-48-6.mol | [Molecular Weight]
430.43 |
| Chemical Properties | Back Directory | [Melting point ]
~185° (dec) | [alpha ]
D25 +17.0° (c = 1 in water) | [storage temp. ]
-20°C Freezer, Under inert atmosphere | [solubility ]
DMSO (Slightly), Water (Slightly) | [form ]
neat | [pka]
pKa1 7.00, pKa2 8.75(at 25℃) | [color ]
White |
| Hazard Information | Back Directory | [Uses]
Spectinomycin Sulfate Tetrahydrate (cas# 64058-48-6) is a compound useful in organic synthesis. | [in vivo]
Spectinomycin dihydrochloride pentahydrate (20 mg/kg; i.m.; 20-100 mg/kg; 9 d) shows the safety in healthy chicks[4].
Spectinomycin dihydrochloride pentahydrate (10 mg/kg; i.v.; single dose) has the major elimination pathway by renal excretion, approximately 55% is excreted into the urine in unchanged form[5].
Pharmacokinetics of Spectinomycin dihydrochloride pentahydrate in Rat[5]
| Parameter | C0 (μg/mL) | AUC0-∞ (μg?h/mL) | Vd (L/kg) | CL (L/h/kg) | MRT (h) | T1/2α (h) | T1/2β (h) | T1/2γ (h) | fe | CLrenal (L/h/kg) | Eratio | | Non atrioventricular analysis | 44.3 | 16.8 | 0.756 | 0.602 | 0.757 | / | / | / | 0.553 | 0.359 | 1.00 | | Three-compartment model | 37.8 | 15.7 | 0.747 | 0.649 | 1.11 | / | 0.237 | 0.754 | 19.5 | / | / |
| Animal Model: | Arbor Acres plus broiler chicks (15-day-old)[4] | | Dosage: | 20 mg/kg, 60 mg/kg, 100 mg/kg | | Administration: | Intramuscular injection (chest muscles); 9 days | | Result: | Showed biosecurity of 20 mg/kg by complete blood count, biochemical parameters, histopathological, clinical signs, body weight gain, and feed conversion ratio (FCR).
Resulted minor toxicity of 60 mg/kg.
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