64118-84-9
中文名称
2-((2,6-二氯-4-羟基苯基)氨基)苯乙酸
英文名称
2-[((2',6'-DICHLORO-4'-HYDROXY)PHENYL)AMINO]BENZENEACETIC ACID
CAS
64118-84-9
分子式
C14H11Cl2NO3
分子量
312.15
MOL 文件
64118-84-9.mol
更新日期
2023/03/20 15:41:17
64118-84-9 结构式
基本信息
中文别名
羟基双氯芬酸4'-羟基双氯芬酸
4'-羟基双氯灭痛
4′-羟基双氯芬酸 溶液
2-((2,6-二氯-4-羟基苯基)氨基)苯乙酸
2-((2,6-二氯-4-羟基苯基)氨基)苯乙酸/4'-羟基双氯灭痛
英文别名
4-OHD4'-OHD
Hydroxydiclofenac
4'-HYDROXYDICLOFENAC
4-HYDROXY DICLOFENAC
DICLOFENAC, 4'-HYDROXY-
4'-HYDROXYDICLOFENAC STANDARD
4′-Hydroxydiclofenac solution
(o-(2,6-dichloro-4-hydroxyanilino)phenyl)aceticacid
(o-(2,6-dichloro-4-hydroxyanilino)phenyl)-aceticaci
所属类别
分析化学:离子色谱试剂物理化学性质
熔点178-185°C dec.
沸点432.7±45.0 °C(Predicted)
密度1.520±0.06 g/cm3(Predicted)
闪点2℃
储存条件−20°C
溶解度溶于DMSO、乙醇或甲醇
酸度系数(pKa)4.17±0.10(Predicted)
形态neat
BRN4198042
稳定性感光
常见问题列表
生物活性
4'-Hydroxy diclofenac 是具有口服活性的 Diclofenac (HY-15036) 通过细胞色素 P450 2C9 (CYP2C9) 的代谢产物。4'-Hydroxy diclofenac 具有抗炎和镇痛作用。体内研究
A single oral administration of Diclofenac to humanized mice, the unchanged drug in plasma peaks at 0.25 hour and then declines with a half-life (t
1/2
) of 2.4 hours. 4'-Hydroxy diclofenac also peaks at 0.25 hour and is undetectable within 24 hours. The plasma concentration of unchanged 4'-Hydroxy diclofenac peaks at 0.25 hour and declines rapidly in Humanized chimeric mice received of 4'-Hydroxy diclofenac (10 mg/kg; a single oral).