| Hazard Information | Back Directory | [Uses]
Atropine (Tropine tropate) hydrobromide is a competitive muscarinic acetylcholine receptor (mAChR) antagonist with IC50 values of 0.39 and 0.71 nM for Human mAChR M4 and Chicken mAChR M4, respectively. Atropine hydrobromide inhibits ACh-induced relaxations in human pulmonary veins. Atropine hydrobromide can be used for research of anti-myopia and bradycardia[1][2][3][4]. | [in vivo]
Atropine (Tropine tropate; 10 mg/kg; i.p.; once, for 40 minutes; Peromyscus sp.) hydrobromide inhibits the cardiac arrhythmia which normally occurs throughout torpor[2]. | Animal Model: | White-footed mice (Peromyscus sp.)[2] | | Dosage: | 10 mg/kg | | Administration: | Intraperitoneal injection; once, for 40 minutes | | Result: | Increased heart rate was a decrease in cardiac arrhythmia. |
| [IC 50]
mAChR4 | [References]
[1] McBrien NA, et, al. How does atropine exert its anti-myopia effects? Ophthalmic Physiol Opt. 2013 May;33(3):373-8. DOI:10.1111/opo.12052
[2] Morhardt JE. Heart rates, breathing rates and the effects of atropine and acetylcholine on white-footed mice (Peromyscus sp.) during daily torpor. Comp Biochem Physiol. 1970 Mar 15;33(2):441-57. DOI:10.1016/0010-406x(70)90360-9
[3] Carr BJ, et, al. Myopia-Inhibiting Concentrations of Muscarinic Receptor Antagonists Block Activation of Alpha2A-Adrenoceptors In Vitro. Invest Ophthalmol Vis Sci. 2018 Jun 1;59(7):2778-2791. DOI:10.1167/iovs.17-22562
[4] Walch L, et, al. Evidence for a M(1) muscarinic receptor on the endothelium of human pulmonary veins. Br J Pharmacol. 2000 May;130(1):73-8. DOI:10.1038/sj.bjp.0703301 |
|
|