| Identification | Back Directory | [Name]
ENMD 547 | [CAS]
644961-61-5 | [Synonyms]
ENMD 547
ENMD1068 HBr
ENMD-1068 HBr
ENMD 1068 HBr
ENMD-1068 Hydrobromide
1-(6-AMino-1-oxohexyl)-4-(3-Methyl-1-oxobutyl)piperazine MonohydrobroMide
6-AMino-1-[4-(3-Methyl-1-oxobutyl)-1-piperazinyl]-1-hexanone HydrobroMide | [Molecular Formula]
C15H30BrN3O2 | [MDL Number]
MFCD18379409 | [MOL File]
644961-61-5.mol | [Molecular Weight]
364.322 |
| Hazard Information | Back Directory | [Chemical Properties]
N/A | [Uses]
A selective PAR-2 antagonist. Dose dependently inhibits calcium signaling in Lewis lung carcinoma cells stimulated with a soluble peptide PAR-2 agonist or trypsin, but not with a soluble PAR-1 agonist. Does not inhibit platelet aggregation stimulated by thrombin suggesting that it does not inhibit PAR-3 or PAR-4 signaling. Reduces TNF-a and IL-1β production from rheumatoid arthritis synovial primary cell culture and reduces joint swelling in a carageenan/kaloin-injected mouse model. | [Uses]
ENMD 547 can be used as a selective PAR-2 antagonist. Dose dependently inhibits calcium signaling in Lewis lung carcinoma cells stimulated with a soluble peptide PAR-2 agonist or trypsin, but not with a soluble PAR-1 agonist.
| [IC 50]
PAR2 |
|
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
|