| Identification | Back Directory | [Name]
6-ACETYL-7-DEACETYLFORSKOLIN | [CAS]
64657-21-2 | [Synonyms]
Coleol B
Coleonol B
Isoforsklin
ISOFORSKOLIN
6-ACETYL-7-DEACETYLFORSKOLIN
FORSKOLIN, 6-ACETYL-7-DEACETYL-
Isoforskolin（ Coleonol B,Excolabdone C）
6-ACETYL-7-DEACETYLFORSKOLIN FROMCOLEUS FORSKOHLII
6β-acetoxy-1α,7β,9α-trihydroxy-8,13-epoxy-labd-14-en-11-one
6BETA-ACETOXY-1ALPHA,7BETA,9ALPHA-TRIHYDROXY-8,13-EPOXY-LABD-14-EN-11-ONE
6BETA-ACETOXY-8,13-EPOXY-1ALPHA,7BETA,9ALPHA-TRIHYDROXY-LABD-14-EN-11-ONE
Isoforskolin, 6β-Acetoxy-1α,7β,9α-trihydroxy-8,13-epoxy-labd-14-en-11-one
(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-6-(Acetyloxy)-3-ethenyldodecahydro-5,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1H-naphtho[2,1-b]pyran-1-one
1H-Naphtho[2,1-b]pyran-1-one,6-(acetyloxy)-3-ethenyldodecahydro-5,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-,(3R,4aR,5S,6S,6aS,10S,10aR,10bS)- | [Molecular Formula]
C22H34O7 | [MDL Number]
MFCD00078929 | [MOL File]
64657-21-2.mol | [Molecular Weight]
410.5 |
| Chemical Properties | Back Directory | [Melting point ]
220-222 °C(Solv: chloroform (67-66-3); methanol (67-56-1)) | [Boiling point ]
524.5±50.0 °C(Predicted) | [density ]
1.23±0.1 g/cm3(Predicted) | [storage temp. ]
−20°C
| [solubility ]
Chloroform: Soluble; DMSO: Soluble | [form ]
A solid | [pka]
11.03±0.70(Predicted) | [color ]
White to off-white | [Optical Rotation]
[α]/D -8 to -5°, c =0.5 in chloroform-d |
| Hazard Information | Back Directory | [Uses]
6-Acetyl-7-deacetylforskolin is a bioactive constituents from the medical plant, Coleus forskohlii. Also, it has anticancer and glucosidase inhibition activities. | [Uses]
Iso-Forskolin is a byproduct in the synthesis of 9-Deoxyforskolin (D239935) from Coleus forskohlii, which is an adenylyl cyclase isoform activator; Antihypertensive. | [General Description]
This substance is supplied with certified chromatographic purity. The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG | [Biological Activity]
Isoforskolin is a naturally occurring diterpene with anti-inflammatory activity. It has been shown to downregulate the expression of proinflammatory compounds. In an experimental mouse model of Lyme Disease induced arthritis isoforskolin downregulated the transcription and expression of TNF-α and IL-6 induced by recombinant Borrelia burgdorferi basic membrane protein A (rBmpA). In a r at asthmatic model isoforskolin down-regulated production of transforming growth factor β1 (TGF-β1) and interleukin-1β (IL-1β) which was accompanied by inhibition of inflammation and airway remodeling. |
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| Company Name: |
Rhawn Reagent
|
| Telephone: |
400-400-1332688 18019345275 |
| Website: |
http://www.rhawn.cn |
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