| Identification | Back Directory | [Name]
Isocurcumenol | [CAS]
24063-71-6 | [Synonyms]
Isocurcumenol
isourecumenol
(+)-Isocurcumenol
6H-3a,6-Epoxyazulen-6-ol, octahydro-3-methyl-8-methylene-5-(1-methylethylidene)-, (3S,3aS,6R,8aS)-
(3S,8aβ)-1,2,3,4,5,7,8,8a-Octahydro-3α-methyl-8-methylene-5-(1-methylethylidene)-6H-3aα,6α-epoxyazulen-6-ol | [Molecular Formula]
C15H22O2 | [MDL Number]
MFCD03792802 | [MOL File]
24063-71-6.mol | [Molecular Weight]
234.33 |
| Chemical Properties | Back Directory | [Melting point ]
142-143℃ | [Boiling point ]
351.0±42.0 °C(Predicted) | [density ]
1.09±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C, protect from light | [solubility ]
DMF: 1 mg/ml,DMSO: 1 mg/ml,Ethanol: slightly soluble | [form ]
Powder | [pka]
12.70±0.40(Predicted) | [color ]
White to off-white | [LogP]
2.837 (est) |
| Hazard Information | Back Directory | [Hazard]
A poison by ingestion. | [Uses]
Isocurcumenol, an estrogen receptor alpha (ERα) inhibitor isolated from Curcuma zedoaria Rhizomes, possesses anti-tumor acticity, with IC50 values of 99.1μg/mL and 178.2 μg/mL in DLA and KB cells, respectively[1][2]. | [target]
5α-Reductase | [storage]
-20°C, protect from light | [References]
[1] Lakshmi S, et al. Antitumour Effects of Isocurcumenol Isolated from Curcuma zedoaria Rhizomes on Human and Murine Cancer Cells. Int J Med Chem. 2011;2011:253962. DOI:10.1155/2011/253962
[2] Resmi Mustarichiei, et al. In silico study of curcumol, curcumenol, isocurcumenol, and β-sitosterol as potential inhibitors of estrogen receptor alpha of breast cancer. Basic Medical Research. 2014 |
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