| Identification | Back Directory | [Name]
schisantherin D | [CAS]
64917-82-4 | [Synonyms]
schisantherin D
(5S)-13,14-Dimethoxy-6α,7β-dimethyl(5,6,7,8-tetrahydrocycloocta[1,2-f:3,4-f']bis[1,3]benzodioxole)-5α,6β-diol 5-benzoate
Cycloocta[1,2-f:3,4-f']bis[1,3]benzodioxole-5,6-diol, 5,6,7,8-tetrahydro-13,14-dimethoxy-6,7-dimethyl-, 5-benzoate, (5S,6S,7S,13aS)- | [Molecular Formula]
C29H28O9 | [MDL Number]
MFCD32644919 | [MOL File]
64917-82-4.mol | [Molecular Weight]
520.53 |
| Hazard Information | Back Directory | [Uses]
Schisantherin D is a dibenzocyclooctadiene lignan isolated from the fruit of Schisandra sphenanthera. Schisantherin D shows anti-HIV replication activities with an EC50 of 0.5 μg/mL. Schisantherin D inhibits endothelin receptor B (ETBR) and has hepatoprotective effects[1][2]. | [References]
[1] D F Chen, et al. Two new lignans, interiotherins A and B, as anti-HIV principles from Kadsura interior. J Nat Prod. 1996 Nov;59(11):1066-8. DOI:10.1021/np9601667
[2] Jin-Biao Xu, et al. Lignans from Schisandra chinensis ameliorate alcohol and CCl 4-induced long-term liver injury and reduce hepatocellular degeneration via blocking ETBR. J Ethnopharmacol. 2020 Aug 10;258:112813. DOI:10.1016/j.jep.2020.112813 |
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