| Identification | Back Directory | [Name]
HYDROXY PENTOXIFYLLINE | [CAS]
6493-06-7 | [Synonyms]
LISOFYLLINE
(+/-)-LISOFYLLINE
Penthydroxifillyne
Lisofylline (racemic)
HYDROXY PENTOXIFYLLINE
5-Hydroxy pentoxifylline
pentoxyfylline metabolite 2
Hydroxy Pentoxifylline (rac-Lisofylline)
3,7-Dihydro-1-(5-hydroxyhexyl)-3,7-diMethyl-
(+/-)-1-(5-HYDROXYHEXYL)-3,7-DIMETHYLXANTHINE
Pentoxifylline Impurity 16 ((+/-)-Lisofylline)
1H-Purine-2,6-dione, 3,7-dihydro-1-(5-hydroxyhexyl)-3,7-dimethyl-
1-(5-hydroxyhexyl)-3,7-dimethylxanthine, pentoxyfylline metabolite 2
1-(5-Hydroxyhexyl)-3,7-dimethyl-1,2,3,6-tetrahydro-7H-purine-2,6-dione
1-(5-hydroxyhexyl)-3,7-dimethylxanthine, pentoxyfylline metabolite 2/(±)-Lisofylline
Hydroxy PentoxifyllineQ: What is
Hydroxy Pentoxifylline Q: What is the CAS Number of
Hydroxy Pentoxifylline Q: What is the storage condition of
Hydroxy Pentoxifylline Q: What are the applications of
Hydroxy Pentoxifylline | [Molecular Formula]
C13H20N4O3 | [MDL Number]
MFCD00867573 | [MOL File]
6493-06-7.mol | [Molecular Weight]
280.32 |
| Chemical Properties | Back Directory | [Melting point ]
123-125°C | [Boiling point ]
511.2±56.0 °C(Predicted) | [density ]
1.32±0.1 g/cm3(Predicted) | [storage temp. ]
Refrigerator | [solubility ]
DMSO: soluble
| [form ]
solid
| [pka]
15.22±0.20(Predicted) | [color ]
white
| [Stability:]
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months. |
| Hazard Information | Back Directory | [Description]
Lisofylline (6493-06-7, racemic) displays anti-inflammatory activity. Regulates immune cell function and autoimmune response by inhibition of IL-12 signalling and cytokine production.1 Protects pancreatic beta cells and prevents type I diabetes in non-obese diabetic mice.2 Lisofylline reduces LPS-induced TNF alpha levels in CD-1 mice.3?Cell permeable. | [Chemical Properties]
White Solid | [Uses]
A major oxidative metabolite of Pentoxifylline. | [Definition]
ChEBI: 1-(5-hydroxyhexyl)-3,7-dimethyl-3,7-dihydro-1H-purine-2,6-dione is a dimethylxanthine that is 3,7-dihydro-1H-purine-2,6-dione which is substituted at positions 1,3 and 7 by a 5-hydroxyhexyl group, methyl group and methyl group, respectively. It is a secondary alcohol and a dimethylxanthine. | [Brand name]
ProTec (Cell
Therapeutics). | [Biological Activity]
A potent inhibitor of phosphatidic acid generation (IC50=0.6 μM). It protects mice from endotoxic shock and attenuates sepsis-induced acute lung injury in the pig. Anti-inflammatory agent. Enhances glucose-stimulated insulin secretion. Inhibits IL-12-mediated STAT4 activation. | [in vitro]
(±)-lisofylline is a potent anti-inflammatory agent in which only the (-) optical isomer is biologically active. (±)-lisofylline was found to inhibit the generation of phosphatidic acid from cytokine-activated lysophosphatidic acyl transferase. (±)-lisofylline could also suppress the production of the proinflammatory cytokine ifn-γ, inhibit il-12-mediated stat-4 activation, as well as enhance glucose-stimulated β-cell insulin secretion [1]. | [in vivo]
in a previous study, lisofylline was administered to female non-obese diabetic mice for 3 weeks. cytokines and blood glucose concentrations were monitored. histology and immunohistochemistry were also carried out in pancreatic sections. results showed that lisofylline was able to suppress ifn-γ production, reduce the onset of insulitis and diabetes, and inhibit diabetes [1]. | [References]
1) Yang?et al. (2005),?Lisofylline: a potential lead for the treatment of diabetes; Biochem. Pharmacol., 69?1
2) Yang?et al. (2002),?The anti-inflammatory compound lisofylline prevents Type I diabetes in non-obese diabetic mice; Diabetologia,?45?1307
3) Wyska?et al. (2010),?Pharmacokinetic-pharmacodynamic modeling of methylxanthine derivatives in mice challenged with high-dose lipopolysaccharide; Pharmacology,?85?264 |
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| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
| Company Name: |
BOC Sciences
|
| Tel: |
16314854226 |
| Website: |
www.bocsci.com |
|