| Identification | Back Directory | [Name]
2H-Purin-2-one,1,3,6,9-tetrahydro-1,3-dimethyl-8-[[2-(4-morpholinyl)ethyl]thio]-6-thioxo- | [CAS]
6505-99-3 | [Synonyms]
JA2131
1,3-dimethyl-8-(2-morpholin-4-ylethylsulfanyl)-6-sulfanylidene-7H-purin-2-one
2H-Purin-2-one,1,3,6,9-tetrahydro-1,3-dimethyl-8-[[2-(4-morpholinyl)ethyl]thio]-6-thioxo- | [Molecular Formula]
C13H19N5O2S2 | [MDL Number]
MFCD34184555 | [MOL File]
6505-99-3.mol | [Molecular Weight]
341.452 |
| Hazard Information | Back Directory | [Uses]
JA2131 is a small molecular inhibitor of Poly(ADP-ribose) Glycohydrolase (PARG) (IC50=0.4 μM). JA2131 regulate DNA damage responses, causes replication fork stalling and cancer cell death[1][2]. | [Biological Activity]
JA2131 is a cell penetrantpotent and selective poly(ADP-ribose) glycohydrolase (PARG) inhibitor th at selectively kills cancer cells. JA2131 induces PARP1 hyper-PARylation and sensitizes cancer cells to radiation-induced DNA damage. JA2131 induces replication fork defects. | [References]
[1] Houl JH, et al. Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death. Nat Commun. 2019 Dec 11;10(1):5654. DOI:10.1038/s41467-019-13508-4
[2] Brosey CA, et al. Targeting SARS-CoV-2 Nsp3 macrodomain structure with insights from human poly(ADP-ribose) glycohydrolase (PARG) structures with inhibitors. Prog Biophys Mol Biol. 2021 Aug;163:171-186. DOI:10.1016/j.pbiomolbio.2021.02.002 |
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DC Chemicals
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Merck KGaA
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Biorbyt Ltd.
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www.biorbyt.com |
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