| Identification | Back Directory | [Name]
4-[(4-(((1,1-DIMETHYLETHYL)OXIDOIMINO)METHYL)PHENOXY)BUTYL]TRIPHENYLPHOSPHONIUM BROMIDE | [CAS]
652968-37-1 | [Synonyms]
MITOPBN
4-[(4-(((1,1-DIMETHYLETHYL)OXIDOIMINO)METHYL)PHENOXY)BUTYL]TRIPHENYLPHOSPHONIUM BROMIDE | [Molecular Formula]
C33H37BrNO2P | [MDL Number]
MFCD09037545 | [MOL File]
652968-37-1.mol | [Molecular Weight]
590.54 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 25 mg/ml; DMF:PBS(pH7.2) (1:2): 0.33 mg/ml; DMSO: 1 mg/ml; Ethanol: 0.33 mg/ml | [form ]
A solid | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
MitoPBN is a mitochondria-targeted antioxidant.1 It accumulates in the mitochondria following the generation of a mitochondrial membrane potential by succinate, an effect that is blocked by addition of the mitochondrial membrane potential uncoupler FCCP . MitoPBN inhibits superoxide activation of mitochondrial uncoupling protein 1 (UCP1), UCP2, and UCP3 when used at a concentration of 250 nM in vitro but does not react with superoxide. It traps hydroxyl (IC50 = ~77 μM) and carbon-centered radicals and inhibits the initiation of lipid peroxidation in isolated bovine heart mitochondria. | [Uses]
MitoPBN is a mitochondria-targeted antioxidant. It accumulates in the mitochondria following the generation of a mitochondrial membrane potential by succinate, an effect that is blocked by addition of the mitochondrial membrane potential uncoupler FCCP. MitoPBN inhibits superoxide activation of mitochondrial uncoupling protein 1 (UCP1), UCP2, and UCP3 when used at a concentration of 250 nM in vitro but does not react with superoxide. It traps hydroxyl (IC50=~77 μM) and carbon-centered radicals and inhibits the initiation of lipid peroxidation in isolated bovine heart mitochondria. | [storage]
Store at -20°C | [References]
1. Murphy, M.P., Echtay, K.S., Blaikie, F.H., et al. Superoxide activates uncoupling proteins by generating carbon-centered radicals and initiating lipid peroxidation: Studies using a mitochondria-targeted spin trap derived from α-phenyl-N-tert-butylnitrone J. Biol. Chem. 278(49),48534-48545(2003). |
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