| Identification | Back Directory | [Name]
OPHIOPOGONIN D | [CAS]
65604-80-0 | [Synonyms]
3)]-β-D-glucopyranoside
(3β,25R)-Spirost-5-en-3-yl 6-deoxy-α-L-mannopyranosyl-(1->
Diosgenin 3-O-[alpha-L-rhamnopyranosyl-(1-2)][beta-D-xylopyranosyl-(1-3)]-beta-D-glucopyranoside
(3β,25R)-Spirost-5-en-3-yl 6-deoxy-α-L-mannopyranosyl-(1->2)-[β-D-xylopyranosyl-(1->3)]-β-D-glucopyranoside
β-D-Glucopyranoside, (3β,25R)-spirost-5-en-3-yl O-6-deoxy-α-L-mannopyranosyl-(1→2)-O-[β-D-xylopyranosyl-(1→3)]- | [Molecular Formula]
C44H70O16 | [MDL Number]
MFCD09970543 | [MOL File]
65604-80-0.mol | [Molecular Weight]
855.02 |
| Chemical Properties | Back Directory | [density ]
1.40 | [solubility ]
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | [form ]
Powder | [pka]
12.78±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Chemical Properties]
White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from Ophiopogon japonicus. | [Uses]
Ophiopogonin D', isolated from the tubers of Ophiopogon japonicus, is a rare naturally occurring C29 steroidal glycoside. Ophiopogonin D' shows cytotoxic activity against two human tumor cell lines MG-63 and SNU387 with IC50s of 3.09 μM and 3.63 μM, respectively[1]. Ophiopogonin D' activates SIRT1 in a dose-dependent manner[2]. | [Biological Activity]
Ophiopogonin D, isolated from the tuber of Ophiopogon japonicus, is a rare naturally occurring C29 steroidal glycoside. Ophiopogonin D' has cytotoxic activity against two human tumor cell lines, MG-63 and SNU387, with IC50s of 3.09 μM and 3.63 μM, respectively. | [target]
| [IC 50]
SIRT1 | [References]
[1] Wang L , et al. Homo-aro-cholestane, furostane and spirostane saponins from the tubers of Ophiopogonjaponicus. Phytochemistry. 2017 Apr;136:125-132. DOI:10.1016/j.phytochem.2017.01.006
[2] Wang Y, et al. Specific Turn-On Fluorescent Probe with Aggregation-Induced EmissionCharacteristics for SIRT1 Modulator Screening and Living-Cell Imaging. Anal Chem. 2015;87(10):5046-9. DOI:10.1021/acs.analchem.5b01069 |
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