| Identification | Back Directory | [Name]
OPHIOPOGONIN D | [CAS]
945619-74-9 | [Synonyms]
Ophiopogonin D
PubChem ID: 46173859
Deacetylophiopogonin C
OPHIOPOGONIN D USP/EP/BP
Ophiopogonin D >=98% (HPLC)
Deacetylophiopogonin C，OJV-V
β-D-Galactopyranoside, (1β,3β,25R)-3-hydroxyspirost-5-en-1-yl O-6-deoxy-α-L-mannopyranosyl-(1→2)-O-[β-D-xylopyranosyl-(1→3)]-6-deoxy- | [Molecular Formula]
C44H70O16 | [MDL Number]
MFCD09970543 | [MOL File]
945619-74-9.mol | [Molecular Weight]
855.03 |
| Chemical Properties | Back Directory | [Melting point ]
263-265 °C | [density ]
1.40 | [storage temp. ]
Sealed in dry,Store in freezer, under -20°C | [solubility ]
DMF:30.0(Max Conc. mg/mL);35.09(Max Conc. mM)
DMSO:30.0(Max Conc. mg/mL);35.09(Max Conc. mM)
Ethanol:15.0(Max Conc. mg/mL);17.54(Max Conc. mM) | [form ]
A solid | [pka]
13.01±0.70(Predicted) | [color ]
White to off-white | [Major Application]
food and beverages | [InChIKey]
FHKHGNFKBPFJCB-UWTSJSSWNA-N |
| Hazard Information | Back Directory | [Uses]
Ophiopogonin D is a natural product isolated from Radix Ophiopogon japonicus that protects the heart against doxorubicin-induced autophagic injury by reduction of both ROS generation and the disruption of the mitochondrial membrane damage. | [Application]
Ophiopogonin D is a bioactive compound that is found in Salvia miltiorrhiza. It has been shown to have hypoglycemic effects and significant cytotoxicity against tumor cells, which may be due to its ability to inhibit glucose uptake. It also causes mitochondrial membrane potential reduction, leading to the induction of apoptosis. This compound also has immunomodulatory effects. In addition, it inhibits the activation of toll-like receptors and prevents the translocation of nuclear factor-κB into the nucleus. Ophiopogonin D also has an effect on bowel disease, myocardial infarcts, and energy metabolism by inhibiting c-jun phosphorylation. | [Definition]
ChEBI: Ophiopogonin D is a steroid saponin. | [Biological Activity]
Ophiopogonin D is a steroidal glycoside extracted from Ophiopogon japonicas th at promotes antioxidative protection of the cardiovascular system. Ophiopogonin D protects the heart against doxorubicin-induced autophagic injury by reduction of both ROS generation and the disruption of the mitochondrial membrane damage. | [Synthesis]
Take maitake dried herbs 500g, crushed through a 40-mesh sieve, add 4L 80% ethanol solution soaked for 0.5 hours, and then placed in a microwave device irradiation extraction for 15min, extraction temperature of 60 ~ 70 ℃, microwave device power set to |
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