| Identification | Back Directory | [Name]
Afurolol | [CAS]
65776-67-2 | [Synonyms]
Afurolol
Afurololum
7-[3-(tert-Butylamino)-2-hydroxypropoxy]isobenzofuran-1(3H)-one
1(3H)-Isobenzofuranone, 7-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]- | [Molecular Formula]
C15H21NO4 | [MDL Number]
MFCD00864583 | [MOL File]
65776-67-2.mol | [Molecular Weight]
279.332 |
| Hazard Information | Back Directory | [Originator]
Afurolol ,ZYF Pharm Chemical | [Manufacturing Process]
A mixture of 18.0 g (0.12 mole) 7-hydroxyphthalide, 180.0 g of 1-chloro-2,3-
epoxypropane (2 moles) and 0.5 ml of piperidine is heated at 100°C for about
5 h and then the unreacted 1-chloro-2,3-epoxypropane is distilled off in
vacuum to yield 12.0 g (48%) of 7-(2,3-epoxypropoxy)phthalide, melting
point 88°-90°C, (crystallized successively from methanol and ethyl acetate).
The 7-(2,3-epoxypropoxy)phthalide is dissolved in methanol and t-butylamine
are added to the solution at about 20°C. The solution is allowed to stand overnight and, the mixture is evaporated in vacuum and the residue is dried
to give 7-(2-hydroxy-3-t-butylamino-propoxy)phthalide. | [Therapeutic Function]
Beta-adrenergic blocker |
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