| Identification | More | [Name]
2-Propoxybenzoic acid | [CAS]
2100-31-4 | [Synonyms]
2-N-PROPOXYBENZOIC ACID
2-PROPOXYBENZOIC ACID
AKOS BBB/270
O-PROPOXY BENZOIC ACID
RARECHEM AL BO 0876
2-n-Propoxybenzoic acid, 98+% | [EINECS(EC#)]
606-685-8 | [Molecular Formula]
C10H12O3 | [MDL Number]
MFCD01075687 | [Molecular Weight]
180.2 | [MOL File]
2100-31-4.mol |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [RTECS ]
000-000-0 | [HS Code ]
29189900 |
| Hazard Information | Back Directory | [Chemical Properties]
Off-White Solid | [Uses]
2-Propoxybenzoic Acid is a salicylic acid derivative used in the preparation of inhibitors of tyrosinase or hyaluronidase. 2-Propoxybenzoic Acid is a very potent inhibitior of collagen-induced aggrega
tion of human platelets | [Uses]
2-Propoxybenzoic Acid is a salicylic acid derivative used in the preparation of inhibitors of tyrosinase or hyaluronidase. 2-Propoxybenzoic Acid is a very potent inhibitior of collagen-induced aggregation of human platelets | [Synthesis]
General procedure for the synthesis of 2-propoxybenzoic acid (PBA) from compound (CAS: 92156-43-9): potassium tert-butoxide (about 11 mmol) was added to a dimethyl sulfoxide (DMSO) solution of compound C (about 9 mmol) and the reaction temperature was maintained at about 0 °C. The reaction mixture was stirred at 0 °C for about 30 minutes, followed by warming up to room temperature (about 25 °C - 30 °C) and continued stirring for 2-3 hours. Upon completion of the reaction, the reaction was quenched with ice water and then extracted with dichloromethane (DCM). The organic layers were combined and dried over anhydrous sodium sulfate (Na2SO4) and subsequently concentrated under reduced pressure. The resulting crude product was purified by recrystallization using ethanol as solvent to afford the target product 2-propoxybenzoic acid (D) with 95% purity. | [References]
[1] Patent: WO2013/160885, 2013, A1. Location in patent: Page/Page column 16
[2] Patent: US2006/167107, 2006, A1. Location in patent: Page/Page column 4 |
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