| Identification | Back Directory | [Name]
CIMICIFUGOSIDE | [CAS]
66176-93-0 | [Synonyms]
CIMICIFUGOSIDE
Prim-O-glucosylcimifygin
CIMICIFUGOSIDE USP/EP/BP
β-D-Xylopyranoside, (3β,12β,16β,23R,24R,25S)-12-(acetyloxy)-16,23:23,26:24,25-triepoxy-26-hydroxy-9,19-cyclolanost-7-en-3-yl | [Molecular Formula]
C37H54O11 | [MDL Number]
MFCD01075142 | [MOL File]
66176-93-0.mol | [Molecular Weight]
674.82 |
| Hazard Information | Back Directory | [Uses]
Cimicifugoside, a triterpenoid isolated from Cimicifuga simplex, is a novel specific nucleoside transport inhibitor that displays synergistic potentiation of methotrexate cytotoxicity[1]. Cimicifugoside shows immunosuppressive activity, which is preferentially directed toward B-cell function with larger doses being required for suppression of T-cell function[2]. | [Biological Activity]
Cimicifugoside, a triterpenoid extracted from Cimicifuga simplex, is a novel specific nucleoside transport inhibitor that synergistically enhances the cytotoxic effect of methotrexate. It has immunosuppressive activity that preferentially targets B cell function, requiring larger doses to inhibit T cell function. | [target]
| [References]
[1] Yawata A, et al. Inhibition of nucleoside transport and synergistic potentiation of methotrexate cytotoxicity by cimicifugoside, a triterpenoid from Cimicifuga simplex. Eur J Pharm Sci. 2009 Nov 5;38(4):355-61. DOI:10.1248/bpb1978.3.643
[2] Hemmi H, et al. The immune response of splenic lymphocytes after cimicifugoside treatment in vitro and pretreatment in vivo. J Pharmacobiodyn. 1980 Dec;3(12):643-8. DOI:10.1248/bpb1978.3.643 |
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Grader reagent
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