| Identification | Back Directory | [Name]
6-CHLORO-2-PICOLINIC ACID METHYL ESTER | [CAS]
6636-55-1 | [Synonyms]
AKOS BBS-00004651
methyl 6-chloropicolinate
6-Chloropicolinic acid methyl ester
methyl (6-chloropyridin-2-yl)acetate
2-chloropyridine-6-carboxylate methyl
methyl 6-chloro-2-pyridinecarboxylate
METHYL 6-CHLOROPYRIDINE-2-CARBOXYLATE
6-CHLORO-2-PICOLINIC ACID METHYL ESTER
methyl 2-(6-chloropyridin-2-yl)acetate
6-chloro-2-picolonic acid methyl ester
Methyl6-chloropyridine-2-carboxylate,95%
Methyl 6-Chloro-2-pyridinecarboxylate >
Methyl 6-Chloropyridine-2-carboxylate, 97+%
6-CHLOROPYRIDINE-2-CARBOXYLIC ACID METHYL ESTER
6-Chloro-2-pyridinecarboxylic acid methyl ester
6-Chloro-2-picolinic acid methyl ester Solution
2-Pyridinecarboxylic acid, 6-chloro-, methyl ester
6-CHLORO-2-PICOLINIC ACID METHYL ESTER ISO 9001：2015 REACH
Methyl 6-chloropicolinate, 2-Chloro-6-(methoxycarbonyl)pyridine | [EINECS(EC#)]
808-173-1 | [Molecular Formula]
C7H6ClNO2 | [MDL Number]
MFCD00155391 | [MOL File]
6636-55-1.mol | [Molecular Weight]
171.58 |
| Chemical Properties | Back Directory | [Melting point ]
93-94° | [Boiling point ]
275.8±20.0 °C(Predicted) | [density ]
1.294±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [form ]
Solid | [pka]
-1.03±0.10(Predicted) | [color ]
Pale yellow | [Water Solubility ]
Slightly soluble in water. | [InChI]
InChI=1S/C7H6ClNO2/c1-11-7(10)5-3-2-4-6(8)9-5/h2-4H,1H3 | [InChIKey]
TWUXBVMXSBEKHA-UHFFFAOYSA-N | [SMILES]
C1(C(OC)=O)=NC(Cl)=CC=C1 |
| Hazard Information | Back Directory | [Uses]
Methyl 6-chloropyridine-2-carboxylate was coupled with 2-(trimethylstannyl)pyridine to afford methyl 2,2?-bipyridine-6-carboxylate. | [Synthesis Reference(s)]
Synthetic Communications, 14, p. 77, 1984 DOI: 10.1080/00397918408060867 | [Synthesis]
6-Chloro-2-picolinic acid methyl ester is prepared by the reaction of methanol and 6-Chloropicolinic acid. The specific synthesis steps are as follows:
Add thionyl chloride (3.7 ml, 50.8 mmol) to a solution of 6-chloropicolinic acid (4.0 g, 25.4 mmol) in methanol (85 ml) at 0 C. Stir the resultant solution for 15 minutes at 0 C, 0.5 hours at room temperature, and 6 hours at 50 C. Concentrate the reaction in vacuo and dilute with CHCl3 (150ml). Wash the organic solution with saturated aqueous sodium bicarbonate (3 x 100 ml), and brine (1 x 100 ml) and dry with sodium sulfate. Filtration and concentration afford methyl 6-chloropicolinate 4.38 g (100 percent) as a white solid. 1H NMR (CDCl3): δ 8.05 (m, 1H), 7.73 (m, 1H), 7.42 (m, 1H), 3.95 (s, 3H).
 | [References]
[1] Patent: WO2004/26871, 2004, A1. Location in patent: Page 43
[2] Patent: WO2007/58482, 2007, A1. Location in patent: Page/Page column 47
[3] Patent: WO2013/102431, 2013, A1. Location in patent: Page/Page column 117
[4] Patent: WO2015/6592, 2015, A1. Location in patent: Page/Page column 52; 53 |
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