| Identification | Back Directory | [Name]
METHYL 6-CHLOROPYRIDAZINE-3-CARBOXYLATE | [CAS]
65202-50-8 | [Synonyms]
CML-037
AKOS 91997
TERT-BUTYL 4-(2-AM...
Methyl 3-chloropyridazine...
6-Chloro-3-(methoxycarbonyl)pyridazine
METHYL 6-CHLOROPYRIDAZINE-3-CARBOXYLATE
Methyl 3-chloropyridazine-6-carboxylate
6-Chloropyridazine-3-carboxylic acid methyl ester
3-Pyridazinecarboxylic acid, 6-chloro-, Methyl ester
METHYL 6-CHLOROPYRIDAZINE-3-CARBOXYLATE ISO 9001：2015 REACH | [Molecular Formula]
C6H5ClN2O2 | [MDL Number]
MFCD08694876 | [MOL File]
65202-50-8.mol | [Molecular Weight]
172.569 |
| Chemical Properties | Back Directory | [Melting point ]
145 °C(Solv: ligroine (8032-32-4)) | [Boiling point ]
310.9±22.0 °C(Predicted) | [density ]
1.372±0.06 g/cm3(Predicted) | [storage temp. ]
Inert atmosphere,2-8°C | [form ]
powder | [pka]
-1.06±0.10(Predicted) | [color ]
Grey | [InChI]
InChI=1S/C6H5ClN2O2/c1-11-6(10)4-2-3-5(7)9-8-4/h2-3H,1H3 | [InChIKey]
FPKXYXKLOWAIOX-UHFFFAOYSA-N | [SMILES]
C1(C(OC)=O)=NN=C(Cl)C=C1 |
| Questions And Answer | Back Directory | [Uses]
6-Chlorpyridazine-3-carboxylic acid methyl ester is a carboxylic acid ester compound that can be used as a key intermediate in the synthesis of compounds with lipid-lowering, anti-tumor proliferation activity, and pesticides. |
| Hazard Information | Back Directory | [Chemical Properties]
Solid | [Synthesis]
B. Methyl 6-hydroxypyridazine-3-carboxylate prepared as described above was mixed with phosphorochloridic acid, slowly heated to reflux temperature and the reaction was maintained for 2.5 hours. Upon completion of the reaction, the mixture was cooled to room temperature and the excess phosphoryl chloride was subsequently evaporated under reduced pressure. The residue was carefully decanted into ice water and the precipitated solid was collected by filtration. The precipitate was washed sequentially with saturated sodium bicarbonate solution and deionized water and finally dried in a vacuum drying oven to afford the target product, methyl 6-chloropyridazine-3-carboxylate, as a yellow solid (4.359 g, 79% yield). | [References]
[1] Patent: EP2316827, 2016, B1. Location in patent: Paragraph 0124
[2] Patent: EP3333157, 2018, A1. Location in patent: Paragraph 0375; 0376; 0394; 0395
[3] Journal of Medicinal Chemistry, 2010, vol. 53, # 9, p. 3814 - 3830 |
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