| Identification | Back Directory | [Name]
LF3 | [CAS]
664969-54-4 | [Synonyms]
LF3
LF3 NEW
LF3;LF-3;LF 3
LF3 >=98% (HPLC)
4-(3-Phenylallyl)-N-(4-sulfamoylphenyl)piperazine-1-carbothioamide
4-[(2E)-3-phenylprop-2-en-1-yl]-N-(4-sulfamoylphenyl)piperazine-1-carbothioamide
1-Piperazinecarbothioamide, N-[4-(aminosulfonyl)phenyl]-4-(3-phenyl-2-propen-1-yl)- | [Molecular Formula]
C20H24N4O2S2 | [MDL Number]
MFCD03352482 | [MOL File]
664969-54-4.mol | [Molecular Weight]
416.56 |
| Chemical Properties | Back Directory | [Boiling point ]
609.6±65.0 °C(Predicted) | [density ]
1.341±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 20mg/mL | [form ]
A solid | [pka]
10.00±0.12(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
N-[4-(Aminosulfonyl)phenyl]-4-(3-phenyl-2-propenyl)-1-piperazinecarbothioamide is a a 4-thioureido-benzenesulfonamide derivative and a Wnt/β-catenin signaling inhibitor. Wnt/β-catenin signaling is involved with embryogenesis and tissue homeostasis. | [Biological Activity]
LF3 is a potent inhibitor of Wnt/β-catenin signaling th at suppresses cancer cells motilitycell-cycle progressionand the overexpression of Wnt target genes. LF3 is a potent and specific antagonist of the interaction between β-catenin and the transcription factor TCF4. LF3 blocks self-renewal of cancer stem cells. | [in vivo]
LF3 reduces tumor growth and induces differentiation in a mouse xenograft model of colon cancer. Tumor growth is significantly reduced when mice with GFPhigh cells are treated with LF3 at 50 mg/kg. LF3 treatment does not disturb the normal histology of the gut of mice[1]. | [storage]
Store at -20°C |
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| Company Name: |
BOC Sciences
|
| Tel: |
|
| Website: |
https://www.bocsci.com |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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