| Identification | Back Directory | [Name]
ansamitocin P-3 | [CAS]
66584-72-3 | [Synonyms]
Tam 330
Tam-330
MTA/CBR32
Nsc292222
Ansamitosin P 3
ANSAMITOCIN P-3
Anasamitocin P-3
Ansamitocin P-3, >98%
Maytansinol isobutyrate
ansamitocin P-3 USP/EP/BP
Ansamitocin P-3 (Maytansinol butyrate)
Ansamitocin P-3（Maytansinol isobutyrate）
ANTIBIOTIC C 15003P3;MAYTANSINOL ISOBUTYRATE
2'-De(acetylmethylamino)-2'-methylmaytansine
2'-De[acetyl(methyl)amino]-2'-methylmaytansine | [Molecular Formula]
C32H43ClN2O9 | [MDL Number]
MFCD00274586 | [MOL File]
66584-72-3.mol | [Molecular Weight]
635.14 |
| Questions And Answer | Back Directory | [Preparation]
Method 1: An extraction, separation, and purification method for ansamitocin P-3, comprising the following steps:
1) Extracting the fermentation broth or solid fermentation medium after fermentation with an extraction solvent to obtain an extract;
2) Concentrating the extract obtained in step 1) until no extraction solvent flows out to obtain a concentrated crude extract A, then adding neutral alumina and mixing it evenly with an organic solvent;
3) Rotating the evenly mixed crude extract A from step 2) until it becomes a dry, sandy substance;
4) Adding an organic solvent to the dry, sandy crude extract A from step 3), shaking and allowing it to stand, and collecting the supernatant;
5) Concentrating the supernatant from step 4), adding silica gel and rotating it until it becomes a sandy substance, and eluting it by gradient column chromatography to obtain ansamitocin P-3. |
| Chemical Properties | Back Directory | [Melting point ]
190-192℃ | [Boiling point ]
833.1±65.0 °C(Predicted) | [density ]
1.29 | [storage temp. ]
2-8°C | [solubility ]
DMSO: 100 mg/mL (157.45 mM);Ethanol: 55 mg/mL (86.60 mM) | [form ]
Solid | [pka]
9.82±0.70(Predicted) | [color ]
White to Off-White | [Water Solubility ]
Water: Insoluble | [InChIKey]
OPQNCARIZFLNLF-VLSFGAMINA-N |
| Hazard Information | Back Directory | [Description]
Ansamitocin P 3 is a macrocyclic antitumor antibiotic that works by depolymerizing microtubules in both interphase and mitosis, and perturbs chromosome segregation. | [Uses]
Ansamitocin P-3 is an antitumor agent that binds to cell division protein FtsZ in Actinosynnema pretiosum. | [Definition]
ChEBI: A polyketide antibiotic that is isolated from Actinosynnema pretiosum and also exhibits antitumour activity. | [IC 50]
Maytansinoids |
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