| Identification | Back Directory | [Name]
3,4-DIHYDROQUINAZOLIN-2(1H)-ONE | [CAS]
66655-67-2 | [Synonyms]
3,4-Dihydro-1H-quizolin-2-one
3,4-DIHYDRO-1H-QUINAZOLIN-2-ONE
3,4-Dihydro-2(1H)-quinazolinone
3,4-DIHYDROQUINAZOLIN-2(1H)-ONE
2(1H)-Quinazolinone, 3,4-dihydro-
1,2,3,4-tetrahydroquinazolin-2-one | [Molecular Formula]
C8H8N2O | [MDL Number]
MFCD03425132 | [MOL File]
66655-67-2.mol | [Molecular Weight]
148.16 |
| Chemical Properties | Back Directory | [Melting point ]
241-242℃ | [Boiling point ]
257℃ | [density ]
1.19 | [Fp ]
120℃ | [storage temp. ]
Sealed in dry,Room Temperature | [pka]
12?+-.0.20(Predicted) |
| Hazard Information | Back Directory | [Synthesis]
The general procedure for the synthesis of 3,4-dihydro-1H-quinazolin-2-one from 2-aminobenzylamine and molybdenum hexacarbonyl was as follows: the reaction was carried out in a two-chamber system. First, 2-aminobenzylamine, Pd(OAc)2 (0.05 eq.) and Cu(OAc)2 (0.5 eq.) were added to the reaction chamber and dissolved in 1,4-dioxane (2 mL). In a CO chamber, Mo(CO)6 (200 mg) was dissolved in 1,4-dioxane (2 mL). Subsequently, 1,8-diazabicyclo[5.4.0]undec-7-ene was added to the system. The two-compartment system was placed in a Dry-Syn heating block and heated to 95°C for the reaction. Upon completion of the reaction, the reaction mixture was filtered through a short silica gel plug and subsequently purified by fast column chromatography. | [References]
[1] Molecules, 2017, vol. 22, # 10, |
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SynAsst Chemical.
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